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Preliminary examination of glucagon-like peptide-1 levels in women with purging disorder and bulimia nervosa.

Title: Preliminary examination of glucagon-like peptide-1 levels in women with purging disorder and bulimia nervosa.
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Name(s): Dossat, Amanda M, author
Bodell, Lindsay P, author
Williams, Diana L, author
Eckel, Lisa A, author
Keel, Pamela K, author
Type of Resource: text
Genre: Journal Article
Text
Date Issued: 2015-03-01
Physical Form: computer
online resource
Extent: 1 online resource
Language(s): English
Abstract/Description: This study examined pre- and postprandial glucagon-like peptide 1 (GLP-1) levels in women with bulimia nervosa (BN), purging disorder (PD), and non-eating disorder control women to better understand whether alterations in satiation-related hormones in BN may be linked to binge-eating episodes or other altered ingestive behaviors. Participants included women with BN (n = 19), PD (n = 14), or controls (n = 14). Participants provided subjective ratings for hunger and fullness and plasma samples before and after consumption of a standardized test meal. As expected, GLP-1 levels increased significantly following test meal consumption; however, participants with BN displayed significantly lower GLP-1 levels compared to PD and control participants both before and after consumption of the test meal. There were no significant differences between PD and control participants in GLP-1 levels, but individuals with PD displayed significantly higher levels of fullness throughout the test meal as compared to both control and BN participants. Our findings provide preliminary evidence that reduced GLP-1 levels in individuals with BN may be associated with binge-eating episodes. Additionally, increased fullness in individuals with PD does not appear to be accounted for by exaggerated postprandial GLP-1 release.
Identifier: FSU_pmch_24590464 (IID), 10.1002/eat.22264 (DOI), PMC4155021 (PMCID), 24590464 (RID), 24590464 (EID)
Keywords: Bulimia nervosa, Glucagon-like peptide-1, Objective binge-eating episode, Purging disorder, Subjective binge-eating episode
Grant Number: M01 RR000059, R01 MH061836, T32 MH093311, R01 MH61836
Publication Note: This NIH-funded author manuscript originally appeared in PubMed Central at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4155021.
Subject(s): Adult
Binge-Eating Disorder/blood
Binge-Eating Disorder/psychology
Bulimia Nervosa/blood
Bulimia Nervosa/psychology
Case-Control Studies
Feeding Behavior/psychology
Feeding and Eating Disorders/blood
Feeding and Eating Disorders/psychology
Female
Glucagon-Like Peptide 1/metabolism
Humans
Hunger/physiology
Postprandial Period/physiology
Satiation/physiology
Persistent Link to This Record: http://purl.flvc.org/fsu/fd/FSU_pmch_24590464
Owner Institution: FSU
Is Part Of: The International journal of eating disorders.
1098-108X
Issue: iss. 2, vol. 48

Choose the citation style.
Dossat, A. M., Bodell, L. P., Williams, D. L., Eckel, L. A., & Keel, P. K. (2015). Preliminary examination of glucagon-like peptide-1 levels in women with purging disorder and bulimia nervosa. The International Journal Of Eating Disorders. Retrieved from http://purl.flvc.org/fsu/fd/FSU_pmch_24590464