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Managing inflammation after spinal cord injury through manipulation of macrophage function.

Title: Managing inflammation after spinal cord injury through manipulation of macrophage function.
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Name(s): Ren, Yi, author
Young, Wise, author
Type of Resource: text
Genre: Journal Article
Text
Date Issued: 2013-01-01
Physical Form: computer
online resource
Extent: 1 online resource
Language(s): English
Abstract/Description: Spinal cord injury (SCI) triggers inflammation with activation of innate immune responses that contribute to secondary injury including oligodendrocyte apoptosis, demyelination, axonal degeneration, and neuronal death. Macrophage activation, accumulation, and persistent inflammation occur in SCI. Macrophages are heterogeneous cells with extensive functional plasticity and have the capacity to switch phenotypes by factors present in the inflammatory microenvironment of the injured spinal cord. This review will discuss the role of different polarized macrophages and the potential effect of macrophage-based therapies for SCI.
Identifier: FSU_pmch_24288627 (IID), 10.1155/2013/945034 (DOI), PMC3833318 (PMCID), 24288627 (RID), 24288627 (EID)
Grant Number: R01 GM100474, R01 GM100474-01
Publication Note: This NIH-funded author manuscript originally appeared in PubMed Central at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3833318.
Subject(s): Cell Differentiation
Cell Proliferation
Cell Survival
Cell Transplantation
Humans
Inflammation/drug therapy
Inflammation/etiology
Macrophages/drug effects
Monocytes/drug effects
Neutrophil Infiltration
Phenotype
Signal Transduction
Spinal Cord Injuries/complications
Spinal Cord Injuries/drug therapy
Persistent Link to This Record: http://purl.flvc.org/fsu/fd/FSU_pmch_24288627
Owner Institution: FSU
Is Part Of: Neural plasticity.
1687-5443
Issue: vol. 2013

Choose the citation style.
Ren, Y., & Young, W. (2013). Managing inflammation after spinal cord injury through manipulation of macrophage function. Neural Plasticity. Retrieved from http://purl.flvc.org/fsu/fd/FSU_pmch_24288627