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Histone deacetylase inhibitors facilitate partner preference formation in female prairie voles.

Title: Histone deacetylase inhibitors facilitate partner preference formation in female prairie voles.
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Name(s): Wang, Hui, author
Duclot, Florian, author
Liu, Yan, author
Wang, Zuoxin, author
Kabbaj, Mohamed, author
Type of Resource: text
Genre: Journal Article
Text
Date Issued: 2013-07-01
Physical Form: computer
online resource
Extent: 1 online resource
Language(s): English
Abstract/Description: In the socially monogamous prairie vole (Microtus ochrogaster), mating induces enduring pair-bonds that are initiated by partner preference formation and regulated by a variety of neurotransmitters, including oxytocin, vasopressin and dopamine. We examined potential epigenetic mechanisms mediating pair-bond regulation and found that the histone deacetylase inhibitors sodium butyrate and trichostatin A (TSA) facilitated partner preference formation in female prairie voles in the absence of mating. This was associated with a specific upregulation of oxytocin receptor (OTR, oxtr) and vasopressin V1a receptor (V1aR, avpr1a) in the nucleus accumbens (NAcc), through an increase in histone acetylation at their respective promoters. Furthermore, TSA-facilitated partner preference was prevented by OTR or V1aR blockade in the NAcc. Notably, mating-induced partner preference triggered the same epigenetic regulation of oxtr and avpr1a gene promoters as TSA. These observations indicate that TSA and mating facilitate partner preference through epigenetic events, providing, to the best of our knowledge, the first direct evidence for epigenetic regulation of pair-bonding.
Identifier: FSU_pmch_23727821 (IID), 10.1038/nn.3420 (DOI), PMC3703824 (PMCID), 23727821 (RID), 23727821 (EID), nn.3420 (PII)
Grant Number: K02 DA023048, R01 MH058616, MHR21-083128, MHR01-058616, R21 MH083128
Publication Note: This NIH-funded author manuscript originally appeared in PubMed Central at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3703824.
Subject(s): Animals
Arvicolinae/physiology
Dose-Response Relationship, Drug
Female
Histone Deacetylase Inhibitors/pharmacology
Hydroxamic Acids/pharmacology
Injections, Intraventricular
Male
Nucleus Accumbens/drug effects
Nucleus Accumbens/metabolism
Pair Bond
RNA, Messenger/metabolism
Receptors, Oxytocin/genetics
Receptors, Oxytocin/metabolism
Receptors, Vasopressin/genetics
Receptors, Vasopressin/metabolism
Sexual Behavior, Animal/drug effects
Time Factors
Up-Regulation/drug effects
Persistent Link to This Record: http://purl.flvc.org/fsu/fd/FSU_pmch_23727821
Owner Institution: FSU
Is Part Of: Nature neuroscience.
1546-1726
Issue: iss. 7, vol. 16

Choose the citation style.
Wang, H., Duclot, F., Liu, Y., Wang, Z., & Kabbaj, M. (2013). Histone deacetylase inhibitors facilitate partner preference formation in female prairie voles. Nature Neuroscience. Retrieved from http://purl.flvc.org/fsu/fd/FSU_pmch_23727821