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Regulation of BDNF expression by cocaine.

Title: Regulation of BDNF expression by cocaine.
Name(s): McCarthy, Deirdre M, author
Brown, Amber N, author
Bhide, Pradeep G, author
Type of Resource: text
Genre: Journal Article
Date Issued: 2012-12-01
Physical Form: computer
online resource
Extent: 1 online resource
Language(s): English
Abstract/Description: Brain-derived neurotrophic factor (BDNF) is a member of the neurotrophin family of growth factors. It is expressed throughout the nervous system. A unique feature of the BDNF gene is the existence of multiple mRNA transcripts, all of which are translated into BDNF protein, suggesting a multilevel regulation of expression. In particular, the BDNF exon IV promoter region is a preferential target for epigenetic alterations, as it contains binding sites for CREB and MeCP2, two transcriptional regulators known to mediate epigenetic changes. Exposure to drugs of abuse is known to modulate epigenetic regulation of BDNF gene expression. This review will discuss how exposure to cocaine, one of the most addictive drugs known to mankind, can produce alterations in BDNF gene expression, especially in the mesolimbic dopaminergic system, which lead to alterations in the reward-mediated behaviors involved in addiction.
Identifier: FSU_pmch_23239946 (IID), PMC3516887 (PMCID), 23239946 (RID), 23239946 (EID)
Keywords: BDNF, Addiction, Animal models, Cocaine, Dopamine, Epigenetics, Synaptic plasticity
Publication Note: This NIH-funded author manuscript originally appeared in PubMed Central at
Subject(s): Animals
Brain-Derived Neurotrophic Factor/genetics
Gene Expression Regulation/drug effects
Prenatal Exposure Delayed Effects
Promoter Regions, Genetic
RNA, Messenger/genetics
Transcription, Genetic
Persistent Link to This Record:
Owner Institution: FSU
Is Part Of: The Yale journal of biology and medicine.
Issue: iss. 4, vol. 85

Choose the citation style.
McCarthy, D. M., Brown, A. N., & Bhide, P. G. (2012). Regulation of BDNF expression by cocaine. The Yale Journal Of Biology And Medicine. Retrieved from