You are here

Ion channels and zinc

Title: Ion channels and zinc: mechanisms of neurotoxicity and neurodegeneration.
1 views
0 downloads
Name(s): Morris, Deborah R, author
Levenson, Cathy W, author
Type of Resource: text
Genre: Journal Article
Text
Date Issued: 2012-01-01
Physical Form: computer
online resource
Extent: 1 online resource
Language(s): English
Abstract/Description: Ionotropic glutamate receptors, such as NMDA, AMPA and kainate receptors, are ligand-gated ion channels that mediate much of the excitatory neurotransmission in the brain. Not only do these receptors bind glutamate, but they are also regulated by and facilitate the postsynaptic uptake of the trace metal zinc. This paper discusses the role of the excitotoxic influx and accumulation of zinc, the mechanisms responsible for its cytotoxicity, and a number of disorders of the central nervous system that have been linked to these neuronal ion channels and zinc toxicity including ischemic brain injury, traumatic brain injury, and epilepsy.
Identifier: FSU_pmch_22645609 (IID), 10.1155/2012/785647 (DOI), PMC3356718 (PMCID), 22645609 (RID), 22645609 (EID)
Publication Note: This NIH-funded author manuscript originally appeared in PubMed Central at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3356718.
Persistent Link to This Record: http://purl.flvc.org/fsu/fd/FSU_pmch_22645609
Owner Institution: FSU
Is Part Of: Journal of toxicology.
1687-8205
Issue: vol. 2012

Choose the citation style.
Morris, D. R., & Levenson, C. W. (2012). Ion channels and zinc: mechanisms of neurotoxicity and neurodegeneration. Journal Of Toxicology. Retrieved from http://purl.flvc.org/fsu/fd/FSU_pmch_22645609