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Sex differences in social interaction behaviors in rats are mediated by extracellular signal-regulated kinase 2 expression in the medial prefrontal cortex.

Title: Sex differences in social interaction behaviors in rats are mediated by extracellular signal-regulated kinase 2 expression in the medial prefrontal cortex.
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Name(s): Carrier, N, author
Kabbaj, M, author
Type of Resource: text
Genre: Journal Article
Text
Date Issued: 2012-06-14
Physical Form: computer
online resource
Extent: 1 online resource
Language(s): English
Abstract/Description: Considerable sex differences occur in the incidence and prevalence of anxiety disorders where women are more anxious than men, particularly in situations where social interaction is required. In preclinical studies, the social interaction test represents a valid animal model to study sex differences in social anxiety. Indeed, female rats engage less in conspecific interactions than their male counterparts, which are behaviors indicative of higher social anxiety in female rats. In this work, we implicated extracellular signal-regulated kinase 2 (ERK2) in the medial prefrontal cortex (mPFC) in mediating social interaction. Indeed, female rats' had lower ERK2 expression compared to male rats, and overexpression of ERK2 in the mPFC increases their social interaction to the level seen in their male counterparts. These data indicate that the sexually dimorphic expression of ERK2 mediates social anxiety-like behaviors.
Identifier: FSU_pmch_22521590 (IID), 10.1016/j.neuroscience.2012.03.041 (DOI), PMC3367089 (PMCID), 22521590 (RID), 22521590 (EID), S0306-4522(12)00308-9 (PII)
Grant Number: R01 MH087583-02, R01 MH087583-01A1, R01 MH087583, R01 MH087583-03, R01 MH087583-04
Publication Note: This NIH-funded author manuscript originally appeared in PubMed Central at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3367089.
Subject(s): Animals
Anxiety Disorders/enzymology
Anxiety Disorders/genetics
Anxiety Disorders/physiopathology
Behavior, Animal/physiology
Female
Male
Mitogen-Activated Protein Kinase 1/drug effects
Mitogen-Activated Protein Kinase 1/genetics
Prefrontal Cortex/enzymology
Rats
Rats, Sprague-Dawley
Sex Characteristics
Social Behavior
Persistent Link to This Record: http://purl.flvc.org/fsu/fd/FSU_pmch_22521590
Owner Institution: FSU
Is Part Of: Neuroscience.
1873-7544
Issue: vol. 212

Choose the citation style.
Carrier, N., & Kabbaj, M. (2012). Sex differences in social interaction behaviors in rats are mediated by extracellular signal-regulated kinase 2 expression in the medial prefrontal cortex. Neuroscience. Retrieved from http://purl.flvc.org/fsu/fd/FSU_pmch_22521590