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Juvenile and adult rats differ in cocaine reward and expression of zif268 in the forebrain.

Title: Juvenile and adult rats differ in cocaine reward and expression of zif268 in the forebrain.
Name(s): Hollis, F, author
Gaval-Cruz, M, author
Carrier, N, author
Dietz, D M, author
Kabbaj, M, author
Type of Resource: text
Genre: Journal Article
Date Issued: 2012-01-03
Physical Form: computer
online resource
Extent: 1 online resource
Language(s): English
Abstract/Description: Adolescents are more likely to experiment with and become addicted to drugs of abuse. A number of studies indicate that the developmental forebrain may be responsible for making adolescents vulnerable to the addictive properties of such drugs. The aim of this study was to first compare behavioral responses to novelty and cocaine between juvenile and adult rats and then compare levels of the immediate-early gene zif268 activation in several forebrain areas via in situ hybridization. We found that juveniles demonstrated higher locomotion scores and required a higher dose of cocaine than adults to establish a conditioned place preference. Additionally, at this higher dose, juvenile rats exhibited higher levels of zif268 mRNA in the prefrontal cortex compared with adults. A developmental effect for increased zif268 mRNA was also observed in the striatum and nucleus accumbens, but there was no interaction with the cocaine dose. These findings hold interesting implications for the study of the molecular mechanisms underlying juvenile drug addiction.
Identifier: FSU_pmch_22056598 (IID), 10.1016/j.neuroscience.2011.10.012 (DOI), PMC3249467 (PMCID), 22056598 (RID), 22056598 (EID), S0306-4522(11)01186-9 (PII)
Grant Number: R21 MH081046-0182, R01 MH087583-01A1, R21 MH081046-01A2, R01 MH087583, R21 MH081046
Publication Note: This NIH-funded author manuscript originally appeared in PubMed Central at
Subject(s): Aging/metabolism
Analysis of Variance
Cocaine/administration & dosage
Conditioning, Operant/drug effects
Conditioning, Operant/physiology
Dopamine Uptake Inhibitors/administration & dosage
Early Growth Response Protein 1/genetics
Early Growth Response Protein 1/metabolism
Gene Expression Regulation/drug effects
Gene Expression Regulation/physiology
Prosencephalon/drug effects
RNA, Messenger/metabolism
Rats, Sprague-Dawley
Persistent Link to This Record:
Owner Institution: FSU
Is Part Of: Neuroscience.
Issue: vol. 200

Choose the citation style.
Hollis, F., Gaval-Cruz, M., Carrier, N., Dietz, D. M., & Kabbaj, M. (2012). Juvenile and adult rats differ in cocaine reward and expression of zif268 in the forebrain. Neuroscience. Retrieved from