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Zinc supplementation provides behavioral resiliency in a rat model of traumatic brain injury.

Title: Zinc supplementation provides behavioral resiliency in a rat model of traumatic brain injury.
Name(s): Cope, Elise C, author
Morris, Deborah R, author
Scrimgeour, Angus G, author
VanLandingham, Jacob W, author
Levenson, Cathy W, author
Type of Resource: text
Genre: Journal Article
Date Issued: 2011-10-24
Physical Form: computer
online resource
Extent: 1 online resource
Language(s): English
Abstract/Description: Depression, anxiety, and impairments in learning and memory are all associated with traumatic brain injury (TBI). Because of the strong link between zinc deficiency, depression, and anxiety, in both humans and rodent models, we hypothesized that dietary zinc supplementation prior to injury could provide behavioral resiliency to lessen the severity of these outcomes after TBI. Rats were fed a marginal zinc deficient (5 ppm), zinc adequate (30 ppm), or zinc supplemented (180 ppm) diet for 4 weeks followed by a moderately-severe TBI using the well-established model of controlled cortical impact (CCI). Following CCI, rats displayed depression-like behaviors as measured by the 2-bottle saccharin preference test for anhedonia. Injury also resulted in evidence of stress and impairments in Morris water maze (MWM) performance compared to sham-injured controls. While moderate zinc deficiency did not worsen outcomes following TBI, rats that were fed the zinc supplemented diet for 4 weeks showed significantly attenuated increases in adrenal weight (p<0.05) as well as reduced depression-like behaviors (p<0.001). Supplementation prior to injury improved resilience such that there was not only significant improvements in cognitive behavior compared to injured rats fed an adequate diet (p<0.01), there were no significant differences between supplemented and sham-operated rats in MWM performance at any point in the 10-day trial. These data suggest a role for supplemental zinc in preventing cognitive and behavioral deficits associated with TBI.
Identifier: FSU_pmch_21699908 (IID), 10.1016/j.physbeh.2011.06.007 (DOI), PMC3506179 (PMCID), 21699908 (RID), 21699908 (EID), S0031-9384(11)00322-2 (PII)
Grant Number: R01 GM081382, R01 GM081382-03
Publication Note: This NIH-funded author manuscript originally appeared in PubMed Central at
Subject(s): Animals
Behavioral Symptoms/diet therapy
Behavioral Symptoms/etiology
Body Weight/drug effects
Body Weight/physiology
Brain Injuries/complications
Choice Behavior
Dietary Supplements
Disease Models, Animal
Eating/drug effects
Maze Learning/drug effects
Rats, Sprague-Dawley
Zinc/administration & dosage
Persistent Link to This Record:
Host Institution: FSU
Is Part Of: Physiology & behavior.
Issue: iss. 5, vol. 104

Choose the citation style.
Cope, E. C., Morris, D. R., Scrimgeour, A. G., VanLandingham, J. W., & Levenson, C. W. (2011). Zinc supplementation provides behavioral resiliency in a rat model of traumatic brain injury. Physiology & Behavior. Retrieved from