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Long-term caloric restriction reduces metabolic rate and heart rate under cool and thermoneutral conditions in FBNF1 rats.

Title: Long-term caloric restriction reduces metabolic rate and heart rate under cool and thermoneutral conditions in FBNF1 rats.
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Name(s): Knight, W David, author
Witte, M M, author
Parsons, A D, author
Gierach, M, author
Overton, J Michael, author
Type of Resource: text
Genre: Journal Article
Text
Date Issued: 2011-05-01
Physical Form: computer
online resource
Extent: 1 online resource
Language(s): English
Abstract/Description: The long-term metabolic and cardiovascular responses to caloric restriction (CR) are poorly understood. We examined the responses to one year of CR in FBNF1 rats housed in cool (COOL; T(a)=15 °C) or thermoneutral (TMN; T(a)=30 °C) conditions. Rats were acclimated to COOL or TMN for 2 months, instrumented for cardiovascular telemetry and studied in calorimeters. Baseline caloric intake, oxygen consumption (VO(2)), mean arterial blood pressure (MAP), and heart rate (HR) were determined prior to assignment to ad lib (AL) or CR groups (30-40% CR) within each T(a) (n = 8). Groups of rats were studied after 10 weeks CR, one year CR, and after 4 days of re-feeding. Both 10 weeks and one year of CR reduced HR and VO(2) irrespective of T(a). Evaluation of the relationship between metabolic organ mass (liver, heart, brain, and kidney mass) and energy expenditure revealed a clear shift induced by CR to reduce expenditure per unit metabolic mass in both COOL and TMN groups. Re-feeding resulted in prompt elevations of HR and VO(2) to levels observed in control rats. These findings are consistent with the hypothesis that long term CR produces sustained reductions in metabolic rate and heart rate in rats.
Identifier: FSU_pmch_21513729 (IID), 10.1016/j.mad.2011.04.001 (DOI), PMC3118456 (PMCID), 21513729 (RID), 21513729 (EID), S0047-6374(11)00046-7 (PII)
Grant Number: R03 AG023837, R03 AG023837-02
Publication Note: This NIH-funded author manuscript originally appeared in PubMed Central at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3118456.
Subject(s): Animals
Caloric Restriction
Cold Temperature
Energy Intake/physiology
Heart Rate/physiology
Male
Organ Size/physiology
Oxygen Consumption/physiology
Rats
Time Factors
Persistent Link to This Record: http://purl.flvc.org/fsu/fd/FSU_pmch_21513729
Owner Institution: FSU
Is Part Of: Mechanisms of ageing and development.
1872-6216
Issue: iss. 5, vol. 132

Choose the citation style.
Knight, W. D., Witte, M. M., Parsons, A. D., Gierach, M., & Overton, J. M. (2011). Long-term caloric restriction reduces metabolic rate and heart rate under cool and thermoneutral conditions in FBNF1 rats. Mechanisms Of Ageing And Development. Retrieved from http://purl.flvc.org/fsu/fd/FSU_pmch_21513729