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THE ROLE OF INTRACELLULAR SODIUM (Na) IN THE REGULATION OF CALCIUM (Ca)-MEDIATED SIGNALING AND TOXICITY.

Title: THE ROLE OF INTRACELLULAR SODIUM (Na) IN THE REGULATION OF CALCIUM (Ca)-MEDIATED SIGNALING AND TOXICITY.
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Name(s): Yu, Xian-Min, author
Groveman, Bradley R, author
Fang, Xiao-Qian, author
Lin, Shuang-Xiu, author
Type of Resource: text
Genre: Journal Article
Text
Date Issued: 2010-01-01
Physical Form: computer
online resource
Extent: 1 online resource
Language(s): English
Abstract/Description: It is known that activated N-methyl-D-aspartate receptors (NMDARs) are a major route of excessive calcium ion (Ca(2+)) entry in central neurons, which may activate degradative processes and thereby cause cell death. Therefore, NMDARs are now recognized to play a key role in the development of many diseases associated with injuries to the central nervous system (CNS). However, it remains a mystery how NMDAR activity is recruited in the cellular processes leading to excitotoxicity and how NMDAR activity can be controlled at a physiological level. The sodium ion (Na(+)) is the major cation in extracellular space. With its entry into the cell, Na(+) can act as a critical intracellular second messenger that regulates many cellular functions. Recent data have shown that intracellular Na(+) can be an important signaling factor underlying the up-regulation of NMDARs. While Ca(2+) influx during the activation of NMDARs down-regulates NMDAR activity, Na(+) influx provides an essential positive feedback mechanism to overcome Ca(2+)-induced inhibition and thereby potentiate both NMDAR activity and inward Ca(2+) flow. Extensive investigations have been conducted to clarify mechanisms underlying Ca(2+)-mediated signaling. This review focuses on the roles of Na(+) in the regulation of Ca(2+)-mediated NMDAR signaling and toxicity.
Identifier: FSU_pmch_21243124 (IID), 10.4236/health.2010.21002 (DOI), PMC3020095 (PMCID), 21243124 (RID), 21243124 (EID)
Grant Number: R01 NS053567, R01 NS053567-04
Publication Note: This NIH-funded author manuscript originally appeared in PubMed Central at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3020095.
Persistent Link to This Record: http://purl.flvc.org/fsu/fd/FSU_pmch_21243124
Owner Institution: FSU
Is Part Of: Health.
1949-4998
Issue: iss. 1, vol. 2

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Yu, X. -M., Groveman, B. R., Fang, X. -Q., & Lin, S. -X. (2010). THE ROLE OF INTRACELLULAR SODIUM (Na) IN THE REGULATION OF CALCIUM (Ca)-MEDIATED SIGNALING AND TOXICITY. Health. Retrieved from http://purl.flvc.org/fsu/fd/FSU_pmch_21243124