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Individual differences in novelty-seeking behavior in rats as a model for psychosocial stress-related mood disorders.

Title: Individual differences in novelty-seeking behavior in rats as a model for psychosocial stress-related mood disorders.
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Name(s): Duclot, Florian, author
Hollis, Fiona, author
Darcy, Michael J, author
Kabbaj, Mohamed, author
Type of Resource: text
Genre: Journal Article
Text
Date Issued: 2011-08-03
Physical Form: computer
online resource
Extent: 1 online resource
Language(s): English
Abstract/Description: Most neuropsychiatric disorders, including stress-related mood disorders, are complex multi-parametric syndromes. Diagnoses are therefore hard to establish and current therapeutic strategies suffer from significant variability in effectiveness, making the understanding of inter-individual variations crucial to unveiling effective new treatments. In rats, such individual differences are observed during exposure to a novel environment, where individuals will exhibit either high or low locomotor activity and can thus be separated into high (HR) and low (LR) responders, respectively. In rodents, a long-lasting, psychosocial, stress-induced depressive state can be triggered by exposure to a social defeat procedure. We therefore analyzed the respective vulnerabilities of HR and LR animals to long-lasting, social defeat-induced behavioral alterations relevant to mood disorders. Two weeks after four daily consecutive social defeat exposures, HR animals exhibit higher anxiety levels, reduced body weight gain, sucrose preference, and a marked social avoidance. LR animals, however, remain unaffected. Moreover, while repeated social defeat exposure induces long-lasting contextual fear memory in both HR and LR animals, only HR individuals exhibit marked freezing behavior four weeks after a single social defeat. Combined, these findings highlight the critical involvement of inter-individual variations in novelty-seeking behavior in the vulnerability to stress-related mood disorders, and uncover a promising model for posttraumatic stress disorder.
Identifier: FSU_pmch_21172365 (IID), 10.1016/j.physbeh.2010.12.014 (DOI), PMC3081532 (PMCID), 21172365 (RID), 21172365 (EID), S0031-9384(10)00461-0 (PII)
Grant Number: R01 MH087583-02, R21 MH081046-0182, R21 MH081046-01A2, R01 MH087583-01A1, R21 MH083128, R21 MH083128-01A2, R01 MH087583, R21 MH081046
Publication Note: This NIH-funded author manuscript originally appeared in PubMed Central at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3081532.
Subject(s): Analysis of Variance
Animals
Avoidance Learning
Conditioning, Classical
Disease Models, Animal
Dominance-Subordination
Exploratory Behavior/physiology
Fear
Female
Food Preferences
Individuality
Male
Memory
Motor Activity/physiology
Orchiectomy
Rats
Rats, Long-Evans
Rats, Sprague-Dawley
Stress, Psychological/physiopathology
Sucrose/administration & dosage
Time Factors
Persistent Link to This Record: http://purl.flvc.org/fsu/fd/FSU_pmch_21172365
Owner Institution: FSU
Is Part Of: Physiology & behavior.
1873-507X
Issue: iss. 2, vol. 104

Choose the citation style.
Duclot, F., Hollis, F., Darcy, M. J., & Kabbaj, M. (2011). Individual differences in novelty-seeking behavior in rats as a model for psychosocial stress-related mood disorders. Physiology & Behavior. Retrieved from http://purl.flvc.org/fsu/fd/FSU_pmch_21172365