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BCL6 canalizes Notch-dependent transcription, excluding Mastermind-like1 from selected target genes during left-right patterning.

Title: BCL6 canalizes Notch-dependent transcription, excluding Mastermind-like1 from selected target genes during left-right patterning.
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Name(s): Sakano, Daisuke, author
Kato, Akiko, author
Parikh, Nisarg, author
McKnight, Kelly, author
Terry, Doris, author
Stefanovic, Branko, author
Kato, Yoichi, author
Type of Resource: text
Genre: Journal Article
Text
Date Issued: 2010-03-16
Physical Form: computer
online resource
Extent: 1 online resource
Language(s): English
Abstract/Description: Although the Notch signaling pathway is one of the most intensely studied intracellular signaling pathways, the mechanisms by which Notch signaling regulates transcription remain incompletely understood. Here, we report that B cell leukemia/lymphoma 6 (BCL6), a transcriptional repressor, is a Notch-associated factor. BCL6 is necessary to maintain the expression of Pitx2 in the left lateral plate mesoderm during the patterning of left-right asymmetry in Xenopus embryos. For this process, BCL6 forms a complex with BCL6 corepressor (BCoR) on the promoters of selected Notch target genes such as enhancer of split related 1. BCL6 also inhibits the transcription of these genes by competing for the Notch1 intracellular domain, preventing the coactivator Mastermind-like1 (MAM1) from binding. These results define a mechanism restricting Notch-activated transcription to cell-type-appropriate subsets of target genes, and elucidate its relevance in vivo during left-right asymmetric development.
Identifier: FSU_pmch_20230751 (IID), 10.1016/j.devcel.2009.12.023 (DOI), PMC2841049 (PMCID), 20230751 (RID), 20230751 (EID), S1534-5807(10)00052-3 (PII)
Grant Number: R03 HD052526, R03 HD052526-01A2, R03 HD052526-02, HD052526
Publication Note: This NIH-funded author manuscript originally appeared in PubMed Central at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2841049.
Subject(s): Animals
Base Sequence
Body Patterning/genetics
Body Patterning/physiology
DNA/genetics
DNA/metabolism
Gene Expression Regulation, Developmental
Homeodomain Proteins/genetics
Homeodomain Proteins/metabolism
In Vitro Techniques
Models, Biological
Molecular Sequence Data
RNA Interference
Receptors, Notch/antagonists & inhibitors
Receptors, Notch/genetics
Receptors, Notch/metabolism
Recombinant Fusion Proteins/metabolism
Repressor Proteins/genetics
Repressor Proteins/metabolism
Signal Transduction
Transcription, Genetic
Xenopus/embryology
Xenopus/genetics
Xenopus/metabolism
Xenopus Proteins/genetics
Xenopus Proteins/metabolism
Persistent Link to This Record: http://purl.flvc.org/fsu/fd/FSU_pmch_20230751
Owner Institution: FSU
Is Part Of: Developmental cell.
1878-1551
Issue: iss. 3, vol. 18

Choose the citation style.
Sakano, D., Kato, A., Parikh, N., McKnight, K., Terry, D., Stefanovic, B., & Kato, Y. (2010). BCL6 canalizes Notch-dependent transcription, excluding Mastermind-like1 from selected target genes during left-right patterning. Developmental Cell. Retrieved from http://purl.flvc.org/fsu/fd/FSU_pmch_20230751