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Female mice and rats exhibit species-specific metabolic and behavioral responses to ovariectomy.

Title: Female mice and rats exhibit species-specific metabolic and behavioral responses to ovariectomy.
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Name(s): Witte, Michelina Messina, author
Resuehr, David, author
Chandler, Ashley R, author
Mehle, Ashlee K, author
Overton, J Michael, author
Type of Resource: text
Genre: Journal Article
Text
Date Issued: 2010-05-01
Physical Form: computer
online resource
Extent: 1 online resource
Language(s): English
Abstract/Description: Ovariectomy (OVX) leads to hyperphagia and weight gain in rats, which can be prevented by estradiol (E2) replacement; however, the role of endogenous E2 on feeding and energy homeostasis in female mice has not been well characterized. The primary goal of this study was to assess the relative contribution of increased energy intake and decreased energy expenditure to OVX-induced weight gain in female rats and mice. OVX led to hyperphagia in rats, but did not produce daily, nor cumulative, hyperphagia in mice. OVX decreased mass-specific metabolic rate in mice, but not in rats. OVX decreased home cage locomotor activity in both species. Pair-feeding attenuated OVX-induced weight gain in rats and produced both short- and long-term changes in expression of key hypothalamic genes involved in food intake and energy homeostasis, i.e., the anorexigenic neuropeptide pro-opiomelanocortin (POMC) and the orexigenic neuropeptides: melanin-concentrating hormone (MCH) and agouti-related peptide (AgRP). No differences in hypothalamic gene expression were observed between OVX'd and sham mice. The results suggest that OVX-induced weight gain is mediated by hyperphagia and reduced locomotor activity in rats, but that in mice, it is primarily mediated by reduced locomotor activity and metabolic rate.
Identifier: FSU_pmch_20067798 (IID), 10.1016/j.ygcen.2010.01.006 (DOI), PMC2856744 (PMCID), 20067798 (RID), 20067798 (EID), S0016-6480(10)00009-2 (PII)
Grant Number: F31 NS057856, F31 NS057856-02, F31 NS057856-01
Publication Note: This NIH-funded author manuscript originally appeared in PubMed Central at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2856744.
Subject(s): Animals
Calorimetry, Indirect
Eating/physiology
Energy Metabolism/physiology
Female
Mice
Mice, Inbred C57BL
Motor Activity/physiology
Neuropeptides/metabolism
Ovariectomy/adverse effects
Pro-Opiomelanocortin
Rats
Rats, Long-Evans
Reverse Transcriptase Polymerase Chain Reaction
Weight Gain/physiology
Persistent Link to This Record: http://purl.flvc.org/fsu/fd/FSU_pmch_20067798
Owner Institution: FSU
Is Part Of: General and comparative endocrinology.
1095-6840
Issue: iss. 3, vol. 166

Choose the citation style.
Witte, M. M., Resuehr, D., Chandler, A. R., Mehle, A. K., & Overton, J. M. (2010). Female mice and rats exhibit species-specific metabolic and behavioral responses to ovariectomy. General And Comparative Endocrinology. Retrieved from http://purl.flvc.org/fsu/fd/FSU_pmch_20067798