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Strong resetting of the mammalian clock by constant light followed by constant darkness.

Title: Strong resetting of the mammalian clock by constant light followed by constant darkness.
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Name(s): Chen, Rongmin, author
Seo, Dong-Oh, author
Bell, Elijah, author
von Gall, Charlotte, author
Lee, Choogon, author
Type of Resource: text
Genre: Journal Article
Text
Date Issued: 2008-11-12
Physical Form: computer
online resource
Extent: 1 online resource
Language(s): English
Abstract/Description: The mammalian molecular circadian clock in the suprachiasmatic nuclei (SCN) regulates locomotor activity rhythms as well as clocks in peripheral tissues (Reppert and Weaver, 2002; Ko and Takahashi, 2006). Constant light (LL) can induce behavioral and physiological arrhythmicity by desynchronizing clock cells in the SCN (Ohta et al., 2005). We examined how the disordered clock cells resynchronize by probing the molecular clock and measuring behavior in mice transferred from LL to constant darkness (DD). The circadian locomotor activity rhythms disrupted in LL become robustly rhythmic again from the beginning of DD, and the starting phase of the rhythm in DD is specific, not random, suggesting that the desynchronized clock cells are quickly reset in an unconventional manner by the L/D transition. By measuring mPERIOD protein rhythms, we showed that the SCN and peripheral tissue clocks quickly become rhythmic again in phase with the behavioral rhythms. We propose that this resetting mechanism may be different from conventional phase shifting, which involves light induction of Period genes (Albrecht et al., 1997; Shearman et al., 1997; Shigeyoshi et al., 1997). Using our functional insights, we could shift the circadian phase of locomotor activity rhythms by 12 h using a 15 h LL treatment: essentially producing phase reversal by a single light pulse, a feat that has not been reported previously in wild-type mice and that has potential clinical utility.
Identifier: FSU_pmch_19005049 (IID), 10.1523/JNEUROSCI.2191-08.2008 (DOI), PMC2626189 (PMCID), 19005049 (RID), 19005049 (EID), 28/46/11839 (PII)
Grant Number: R01 NS053616, R01 NS053616-03, NS-053616
Publication Note: This NIH-funded author manuscript originally appeared in PubMed Central at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2626189.
Subject(s): Animals
Biological Clocks/physiology
Biological Clocks/radiation effects
Cell Cycle Proteins/genetics
Cell Cycle Proteins/metabolism
Circadian Rhythm/physiology
Circadian Rhythm/radiation effects
Darkness
Light
Male
Mice
Mice, Inbred C57BL
Motor Activity/physiology
Motor Activity/radiation effects
Nuclear Proteins/genetics
Nuclear Proteins/metabolism
Period Circadian Proteins
Photic Stimulation
Suprachiasmatic Nucleus/metabolism
Suprachiasmatic Nucleus/radiation effects
Transcription Factors/genetics
Transcription Factors/metabolism
Persistent Link to This Record: http://purl.flvc.org/fsu/fd/FSU_pmch_19005049
Owner Institution: FSU
Is Part Of: The Journal of neuroscience : the official journal of the Society for Neuroscience.
1529-2401
Issue: iss. 46, vol. 28

Choose the citation style.
Chen, R., Seo, D. -O., Bell, E., Von Gall, C., & Lee, C. (2008). Strong resetting of the mammalian clock by constant light followed by constant darkness. The Journal Of Neuroscience : The Official Journal Of The Society For Neuroscience. Retrieved from http://purl.flvc.org/fsu/fd/FSU_pmch_19005049