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Effects of chronic environmental and social stimuli during adolescence on mesolimbic dopaminergic circuitry markers.

Title: Effects of chronic environmental and social stimuli during adolescence on mesolimbic dopaminergic circuitry markers.
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Name(s): Kabbaj, M, author
Isgor, C, author
Type of Resource: text
Genre: Journal Article
Text
Date Issued: 2007-07-05
Physical Form: computer
online resource
Extent: 1 online resource
Language(s): English
Abstract/Description: Previously, we have shown that chronic exposure to environmental and social stimuli (ESS) during adolescence prevents the development of behavioral sensitization to amphetamine in adult rats. At the onset of the peripubertal-juvenile period (28-d) male rats were subjected to a 28-d long intermittent ESS protocol or handled as controls (NO-ESS). Twenty-four hours after the last session of ESS or NO-ESS, all rats started a regimen of behavioral sensitization to amphetamine (1mg/kg, i.p.), in which rats were injected every third day with amphetamine or saline on four occasions. Then following one week abstinence all rats were challenged with a lower dose of amphetamine (0.5mg/kg, i.p.) and their locomotor activity monitored for 2h. Our results showed that while NO-ESS rats developed behavioral sensitization to amphetamine, ESS rats did not develop this behavior. All rats were then sacrificed 3 days following the challenge to allow for amphetamine clearance. Since mesolimbic dopamine has been implicated in behavioral sensitization to amphetamine we compared messenger RNA (mRNA) expression of key dopamine-related molecules in the mesolimbic circuitry in ESS and NO-ESS rats. A decrease in dopaminergic D1 receptor (D1R) gene expression in the caudate-putamen (CPu) was associated with amphetamine sensitization in the controls, possibly as a result of a chronic increase in DA release. In contrast, amphetamine treatment did not modulate D1R mRNA levels in ESS rats. No change has been detected in any other dopaminergic markers [D2R, D3R, tyrosine hydroxylase (TH) or dopamine transporter (DAT) mRNAs]. Consequently, we conclude that ESS may inhibit the development of behavioral sensitization to amphetamine through preventing the decrease in CPu D1R mRNA levels.
Identifier: FSU_pmch_17590508 (IID), 10.1016/j.neulet.2007.04.088 (DOI), PMC2080836 (PMCID), 17590508 (RID), 17590508 (EID), S0304-3940(07)00507-1 (PII)
Grant Number: R01 DA019627, R01 DA019627-01, R03 DA021554, R03 DA021554-02
Publication Note: This NIH-funded author manuscript originally appeared in PubMed Central at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2080836.
Subject(s): Animals
Behavior, Animal/drug effects
Dextroamphetamine/pharmacology
Dopamine/physiology
Dopamine Plasma Membrane Transport Proteins/metabolism
Dopamine Uptake Inhibitors/pharmacology
Environment
In Situ Hybridization
Limbic System/growth & development
Limbic System/physiology
Male
Nerve Net/growth & development
Nerve Net/physiology
RNA, Messenger/biosynthesis
RNA, Messenger/genetics
Rats
Rats, Sprague-Dawley
Receptors, Dopamine/drug effects
Receptors, Dopamine/metabolism
Social Environment
Tissue Fixation
Tyrosine 3-Monooxygenase/metabolism
Persistent Link to This Record: http://purl.flvc.org/fsu/fd/FSU_pmch_17590508
Owner Institution: FSU
Is Part Of: Neuroscience letters.
0304-3940
Issue: iss. 1, vol. 422

Choose the citation style.
Kabbaj, M., & Isgor, C. (2007). Effects of chronic environmental and social stimuli during adolescence on mesolimbic dopaminergic circuitry markers. Neuroscience Letters. Retrieved from http://purl.flvc.org/fsu/fd/FSU_pmch_17590508