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Enhanced Cellular Uptake Of Size-separated Lipophilic Silicon Nanoparticles

Title: Enhanced Cellular Uptake Of Size-separated Lipophilic Silicon Nanoparticles.
Name(s): Kusi-Appiah, Aubrey E., author
Mastronardi, Melanie L., author
Qian, Chenxi, author
Chen, Kenneth K., author
Ghazanfari, Lida, author
Prommapan, Plengchart, author
Kuebel, Christian, author
Ozin, Geoffrey A., author
Lenhert, Steven, author
Type of Resource: text
Genre: Journal Article
Journal Article
Date Issued: 2017-03-08
Physical Form: computer
online resource
Extent: 1 online resource
Language(s): English
Abstract/Description: Specific size, shape and surface chemistry influence the biological activity of nanoparticles. In the case of lipophilic nanoparticles, which are widely used in consumer products, there is evidence that particle size and formulation influences skin permeability and that lipophilic particles smaller than 6 nm can embed in lipid bilayers. Since most nanoparticle synthetic procedures result in mixtures of different particles, post-synthetic purification promises to provide insights into nanostructure-function relationships. Here we used size-selective precipitation to separate lipophilic allyl-benzyl-capped silicon nanoparticles into monodisperse fractions within the range of 1 nm to 5 nm. We measured liposomal encapsulation and cellular uptake of the monodisperse particles and found them to have generally low cytotoxicities in Hela cells. However, specific fractions showed reproducibly higher cytotoxicity than other fractions as well as the unseparated ensemble. Measurements indicate that the cytotoxicity mechanism involves oxidative stress and the differential cytotoxicity is due to enhanced cellular uptake by specific fractions. The results indicate that specific particles, with enhanced suitability for incorporation into lipophilic regions of liposomes and subsequent in vitro delivery to cells, are enriched in certain fractions.
Identifier: FSU_libsubv1_wos_000395755000001 (IID), 10.1038/srep43731 (DOI)
Keywords: quantum dots, drug-delivery, dependent cytotoxicity, gold nanoparticles, in-vitro toxicity, lipid multilayer microarrays, mammalian-cells, metal-oxide nanoparticles, oxidative stress, silver nanoparticles
Publication Note: The publisher's version of record is available at
Persistent Link to This Record:
Host Institution: FSU
Is Part Of: Scientific Reports.
Issue: vol. 7

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Kusi-Appiah, A. E., Mastronardi, M. L., Qian, C., Chen, K. K., Ghazanfari, L., Prommapan, P., … Lenhert, S. (2017). Enhanced Cellular Uptake Of Size-separated Lipophilic Silicon Nanoparticles. Scientific Reports. Retrieved from