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Histone Posttranslational Modifications Predict Specific Alternative Exon Subtypes In Mammalian Brain

Title: Histone Posttranslational Modifications Predict Specific Alternative Exon Subtypes In Mammalian Brain.
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Name(s): Hu, Qiwen, author
Kim, Eun Ji, author
Feng, Jian, author
Grant, Gregory R., author
Heller, Elizabeth A., author
Type of Resource: text
Genre: Journal Article
Text
Journal Article
Date Issued: 2017-06
Physical Form: computer
online resource
Extent: 1 online resource
Language(s): English
Abstract/Description: A compelling body of literature, based on next generation chromatin immunoprecipitation and RNA sequencing of reward brain regions indicates that the regulation of the epigenetic landscape likely underlies chronic drug abuse and addiction. It is now critical to develop highly innovative computational strategies to reveal the relevant regulatory transcriptional mechanisms that may underlie neuropsychiatric disease. We have analyzed chromatin regulation of alternative splicing, which is implicated in cocaine exposure in mice. Recent literature has described chromatin-regulated alternative splicing, suggesting a novel function for drug-induced neuroepigenetic remodeling. However, the extent of the genome-wide association between particular histone modifications and alternative splicing remains unexplored. To address this, we have developed novel computational approaches to model the association between alternative splicing and histone posttranslational modifications in the nucleus accumbens (NAc), a brain reward region. Using classical statistical methods and machine learning to combine ChIP-Seq and RNA-Seq data, we found that specific histone modifications are strongly associated with various aspects of differential splicing. H3K36me3 and H3K4me1 have the strongest association with splicing indicating they play a significant role in alternative splicing in brain reward tissue.
Identifier: FSU_libsubv1_wos_000404565400051 (IID), 10.1371/journal.pcbi.1005602 (DOI)
Keywords: mechanisms, chromatin, cocaine-induced plasticity, roles
Publication Note: The publisher's version of record is available at https://doi.org/10.1371/journal.pcbi.1005602
Persistent Link to This Record: http://purl.flvc.org/fsu/fd/FSU_libsubv1_wos_000404565400051
Owner Institution: FSU
Is Part Of: Plos Computational Biology.
1553-734X
Issue: iss. 6, vol. 13

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Hu, Q., Kim, E. J., Feng, J., Grant, G. R., & Heller, E. A. (2017). Histone Posttranslational Modifications Predict Specific Alternative Exon Subtypes In Mammalian Brain. Plos Computational Biology. Retrieved from http://purl.flvc.org/fsu/fd/FSU_libsubv1_wos_000404565400051