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Effects of vitamin e on bone biomechanical and histomorphometric parameters in ovariectomized rats.

Title: Effects of vitamin e on bone biomechanical and histomorphometric parameters in ovariectomized rats.
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Name(s): Feresin, Rafaela G, author
Johnson, Sarah A, author
Elam, Marcus L, author
Kim, Jeong-Su, author
Khalil, Dania A, author
Lucas, Edralin A, author
Smith, Brenda J, author
Payton, Mark E, author
Akhter, Mohammed P, author
Arjmandi, Bahram H, author
Type of Resource: text
Genre: Journal Article
Text
Date Issued: 2013-01-01
Physical Form: computer
online resource
Extent: 1 online resource
Language(s): English
Abstract/Description: The present study examined the dose-dependent effect of vitamin E in reversing bone loss in ovariectomized (Ovx) rats. Sprague-Dawley rats were either Sham-operated (Sham) or Ovx and fed control diet for 120 days to lose bone. Subsequently, rats were divided into 5 groups (n = 12/group): Sham, Ovx-control, low dose (Ovx + 300 mg/kg diet; LD), medium dose (Ovx + 525 mg/kg diet; MD), and high dose (Ovx + 750 mg/kg diet; HD) of vitamin E and sacrificed after 100 days. Animals receiving MD and HD of vitamin E had increased serum alkaline phosphatase compared to the Ovx-control group. Bone histomorphometry analysis indicated a decrease in bone resorption as well as increased bone formation and mineralization in the Ovx groups supplemented with MD and HD of vitamin E. Microcomputed tomography findings indicated no effects of vitamin E on trabecular bone of fifth lumbar vertebrae. Animals receiving HD of vitamin E had enhanced fourth lumbar vertebra quality as evidenced by improved ultimate and yield load and stress when compared to Ovx-control group. These findings demonstrate that vitamin E improves bone quality, attenuates bone resorption, and enhances the rate of bone formation while being unable to restore bone density and trabecular bone structure.
Identifier: FSU_pmch_24089643 (IID), 10.1155/2013/825985 (DOI), PMC3780659 (PMCID), 24089643 (RID), 24089643 (EID)
Publication Note: This NIH-funded author manuscript originally appeared in PubMed Central at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3780659.
Persistent Link to This Record: http://purl.flvc.org/fsu/fd/FSU_pmch_24089643
Owner Institution: FSU
Is Part Of: Journal of osteoporosis.
2090-8059
Issue: vol. 2013

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Feresin, R. G., Johnson, S. A., Elam, M. L., Kim, J. -S., Khalil, D. A., Lucas, E. A., … Arjmandi, B. H. (2013). Effects of vitamin e on bone biomechanical and histomorphometric parameters in ovariectomized rats. Journal Of Osteoporosis. Retrieved from http://purl.flvc.org/fsu/fd/FSU_pmch_24089643