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Beta-hydroxy-beta-methyl-butyrate blunts negative age-related changes in body composition, functionality and myofiber dimensions in rats.

Title: Beta-hydroxy-beta-methyl-butyrate blunts negative age-related changes in body composition, functionality and myofiber dimensions in rats.
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Name(s): Wilson, Jacob M, author
Grant, Samuel C, author
Lee, Sang-Rok, author
Masad, Ihssan S, author
Park, Young-Min, author
Henning, Paul C, author
Stout, Jeffery R, author
Loenneke, Jeremy P, author
Arjmandi, Bahram H, author
Panton, Lynn B, author
Kim, Jeong-Su, author
Type of Resource: text
Genre: Journal Article
Text
Date Issued: 2012-04-18
Physical Form: computer
online resource
Extent: 1 online resource
Language(s): English
Abstract/Description: To determine the effects of 16 wk. of beta-hydroxy-beta-methylbutyrate (HMB) administration on age-related changes in functionality and diffusion tensor imaging (DTI) determined myofiber dimensions. Twelve young (44 wk.), 6 middle-aged (60 wk.), 10 old (86 wk.), and 5 very old (102 wk.) male Fisher-344 rat's body composition and grip strength were assessed at baseline. Following, 6 young, 6 middle-aged, 5 old and 5 very old rats were sacrificed for baseline myofiber dimensions and gene transcript factor expression in the soleus (SOL) and gastrocnemius (GAS). The remaining 6 young and 5 old rats were given HMB for 16 wk. and then sacrificed. Fat mass increased in the middle-aged control condition (+49%) but not the middle-aged HMB condition. In addition, fat mass declined (-56%) in the old HMB condition but not the old control condition. Normalized strength declined and maintained respectively in the control and HMB conditions from 44 to 60 wk. and increased (+23%) (p < 0.05) from 86 to 102 wk. in only the HMB condition. Declines occurred in myofiber size in all muscles from 44 to 102 wk. in the control condition(-10 to -15%), but not HMB condition. Atrogin-1 mRNA expression in the SOL and GAS muscles was greater in the 102-wk control condition than all other conditions: SOL (+45%) and GAS (+100%). This elevation was blunted by HMB in the 102 wk. old SOL. There was a condition effect in the SOL for myogenin, which significantly increased (+40%) only in the 102-wk. HMB group relative to the 44-wk. group. HMB may blunt age-related losses of strength and myofiber dimensions, possibly through attenuating the rise in protein breakdown.
Identifier: FSU_pmch_22512917 (IID), 10.1186/1550-2783-9-18 (DOI), PMC3356228 (PMCID), 22512917 (RID), 22512917 (EID), 1550-2783-9-18 (PII)
Publication Note: This NIH-funded author manuscript originally appeared in PubMed Central at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3356228.
Persistent Link to This Record: http://purl.flvc.org/fsu/fd/FSU_pmch_22512917
Owner Institution: FSU
Is Part Of: Journal of the International Society of Sports Nutrition.
1550-2783
Issue: iss. 1, vol. 9

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Wilson, J. M., Grant, S. C., Lee, S. -R., Masad, I. S., Park, Y. -M., Henning, P. C., … Kim, J. -S. (2012). Beta-hydroxy-beta-methyl-butyrate blunts negative age-related changes in body composition, functionality and myofiber dimensions in rats. Journal Of The International Society Of Sports Nutrition. Retrieved from http://purl.flvc.org/fsu/fd/FSU_pmch_22512917