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Cooccurrence of Obesity, Osteoporosis, and Sarcopenia in the Ovariectomized Rat

Title: The Cooccurrence of Obesity, Osteoporosis, and Sarcopenia in the Ovariectomized Rat: A Study for Modeling Osteosarcopenic Obesity in Rodents.
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Name(s): Ezzat-Zadeh, Zahra, author
Kim, Jeong-Su, author
Chase, P Bryant, author
Arjmandi, Bahram H, author
Type of Resource: text
Genre: Journal Article
Text
Date Issued: 2017-01-01
Physical Form: computer
online resource
Extent: 1 online resource
Language(s): English
Abstract/Description: Obesity, osteoporosis, and sarcopenia may individually occur due to age-related gradual alterations in body composition. This study investigates the cooccurrence of these age-related diseases in female animals with low levels of ovarian hormone in the absence of complex multifactorial process of chronological aging. Thirty-six 5- and 10-month-old female rats were chosen to model pre- and postmenopausal women, respectively. Rats were divided into three treatment groups in each age category-sham, ovariectomized (ovx), and ovx + E2 (17β-estradiol, 10 μg/kg)-and were pair-fed. Volunteer wheel running activity, body composition, bone microstructure, serum C-telopeptides of type I collagen, bone specific alkaline phosphatase, E2, and gastrocnemius and soleus muscles were analyzed. The cooccurrence of osteoporosis, sarcopenia, and obesity was observed in the older ovx rats associated with a significant (p < 0.05) increased fat mass (30%), bone loss (9.6%), decreased normalized muscle mass-to-body-weight ratio (10.5%), and a significant decrease in physical activity (57%). The ratio of tibial bone mineral density to combined muscle mass was significantly decreased in both ovx age categories. Ovariectomized rat could be used as an experimental model to examine the effect of loss of ovarian hormones, while controlling for energy intake and expenditure, to conduct obesity and body composition translational research in females without the confounding effect of genetic background.
Identifier: FSU_pmch_28656107 (IID), 10.1155/2017/1454103 (DOI), PMC5471594 (PMCID), 28656107 (RID), 28656107 (EID)
Publication Note: This NIH-funded author manuscript originally appeared in PubMed Central at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5471594.
Persistent Link to This Record: http://purl.flvc.org/fsu/fd/FSU_pmch_28656107
Owner Institution: FSU
Is Part Of: Journal of aging research.
2090-2204
Issue: vol. 2017

Choose the citation style.
Ezzat-Zadeh, Z., Kim, J. -S., Chase, P. B., & Arjmandi, B. H. (2017). The Cooccurrence of Obesity, Osteoporosis, and Sarcopenia in the Ovariectomized Rat: A Study for Modeling Osteosarcopenic Obesity in Rodents. Journal Of Aging Research. Retrieved from http://purl.flvc.org/fsu/fd/FSU_pmch_28656107