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Modeling Cortical Folding Patterns on a Growing Oblate Spheroid Domain

Title: Modeling Cortical Folding Patterns on a Growing Oblate Spheroid Domain.
Name(s): Morie, Raymond, author
Type of Resource: text
Genre: text
bachelor thesis
Date Issued: 2017-04-28
Physical Form: computer
Physical Form: online resource
Extent: 1 online resource
Language(s): English
Abstract/Description: Many of the mechanisms involved in brain development are not definitively understood. This includes the mechanism by which the folds of the cerebral cortex, called gyri and sulci, are formed. This research adopts the Intermediate Progenitor Model, which emphasizes genetic chemical factor control. This model is based on a hypothesis that activation of radial glial cells produces intermediate progenitor cells that in turn correspond to gyral wall formation. In previous work, Toole and Hurdal developed two biomathematical models that use a Turing reaction-diffusion system on a prolate spheroid domain. These models examined the effect that different domain growth functions had on cortical folding pattern formation. In this research, we modify those models to utilize an oblate spheroid domain. By analyzing the role of various parameters, we seek to use this modified domain to model diseases such as holoprosencephaly and ventriculomegaly, which alter the shape of the lateral ventricle.
Identifier: FSU_libsubv1_scholarship_submission_1493406924 (IID)
Keywords: Turing System, Cortical Folding, Holoprosencephaly, Ventriculomegaly, Oblate Spheroid
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Owner Institution: FSU