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Prediction Of Individual Differences In Fear Response By Novelty Seeking, And Disruption Of Contextual Fear Memory Reconsolidation By Ketamine

Title: Prediction Of Individual Differences In Fear Response By Novelty Seeking, And Disruption Of Contextual Fear Memory Reconsolidation By Ketamine.
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Name(s): Duclot, Florian, author
Perez-Taboada, Iara, author
Wright, Katherine N., author
Kabbaj, Mohamed, author
Type of Resource: text
Genre: Text
Date Issued: 2016-10
Physical Form: computer
online resource
Extent: 1 online resource
Language(s): English
Abstract/Description: Only a portion of the population exposed to trauma will develop persistent emotional alterations characteristic of posttraumatic stress disorder (PTSD), which illustrates the necessity for identifying vulnerability factors and novel pharmacotherapeutic alternatives. Interestingly, clinical evidence suggests that novelty seeking is a good predictor for vulnerability to the development of excessive and persistent fear. Here, we first tested this hypothesis by analyzing contextual and cued fear responses of rats selected for their high (high responders, HR) or low (low responders, LR) exploration of a novel environment, indicator of novelty seeking. While HR and LR rats exhibited similar sensitivity to the shock and cued fear memory retention, fewer extinction sessions were required in HR than LR animals to reach extinction, indicating faster contextual and cued memory extinction. In a second part, we found an effective disruption of contextual fear reconsolidation by the N-methyl-D-aspartate receptor antagonist ketamine, associated with a down-regulation of early growth response 1 (Egr1) in the hippocampal CA1 area, and up-regulation of brain-derived neurotrophic factor (Bdnf) mRNA levels in the prelimbic and infralimbic cortices. Altogether, these data demonstrate a link between novelty seeking and conditioned fear extinction, and highlight a promising novel role of ketamine in affecting established fear memory. (C) 2016 Elsevier Ltd. All rights reserved.
Identifier: FSU_libsubv1_wos_000381950700029 (IID), 10.1016/j.neuropharm.2016.06.022 (DOI)
Keywords: animal-models, Anxiety disorders, BDNF, conditioned fear, extinction, Fear conditioning, Fear extinction, Fear memory reconsolidation, hippocampal, Individual differences, Ketamine, neural mechanisms, Novelty seeking, posttraumatic-stress-disorder, rats, social defeat
Publication Note: The publisher's version of record is available at https://doi.org/10.1016/j.neuropharm.2016.06.022
Persistent Link to This Record: http://purl.flvc.org/fsu/fd/FSU_libsubv1_wos_000381950700029
Owner Institution: FSU
Is Part Of: Neuropharmacology.
0028-3908
Issue: vol. 109

Choose the citation style.
Duclot, F., Perez-Taboada, I., Wright, K. N., & Kabbaj, M. (2016). Prediction Of Individual Differences In Fear Response By Novelty Seeking, And Disruption Of Contextual Fear Memory Reconsolidation By Ketamine. Neuropharmacology. Retrieved from http://purl.flvc.org/fsu/fd/FSU_libsubv1_wos_000381950700029