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Behavioral Evidence for More than One Taste Signaling Pathway for Sugars in Rats

Title: Behavioral Evidence for More than One Taste Signaling Pathway for Sugars in Rats.
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Name(s): Schier, Lindsey A., author
Spector, Alan C., author
Type of Resource: text
Genre: Text
Date Issued: 2016-01-06
Physical Form: computer
online resource
Extent: 1 online resource
Language(s): English
Abstract/Description: By conventional behavioral measures, rodents respond to natural sugars, such as glucose and fructose, as though they elicit an identical perceptual taste quality. Beyond that, the metabolic and sensory effects of these two sugars are quite different. Considering the capacity to immediately respond to the more metabolically expedient sugar, glucose, would seem advantageous for energy intake, the present experiment assessed whether experience consuming these two sugars would modify taste-guided ingestive responses to their yet unknown distinguishing orosensory properties. One group (GvF) had randomized access to three concentrations of glucose and fructose (0.316, 0.56, 1.1 M) in separate 30-min single access training sessions, whereas control groups received equivalent exposure to the three glucose or fructose concentrations only, or remained sugar naive. Comparison of the microstructural licking patterns for the two sugars revealed that GvF responded more positively to glucose (increased total intake, increased burst size, decreased number of pauses), relative to fructose, across training. As training progressed, GvF rats began to respond more positively to glucose in the first minute of the session when intake is principally taste-driven. During post-training brief-access taste tests, GvF rats licked more for glucose than for fructose, whereas the other training groups did not respond differentially to the two sugars. Additional brief access testing showed that this did not generalize to Na-saccharin or galactose. Thus, in addition to eliciting a common taste signal, glucose and fructose produce distinct signals that are apparently rendered behaviorally relevant and hedonically distinct through experience. The taste pathway(s) underlying this remain to be identified.
Identifier: FSU_libsubv1_wos_000368348100014 (IID), 10.1523/JNEUROSCI.3356-15.2016 (DOI)
Keywords: appetition, c57bl/6j mice, cephalic-phase, flavor preferences, food-deprivation, glucose transporters, gustatory system, knockout mice, licking behavior, licking microstructure, mammalian sweet, sucrose, sweeteners, T1R2+T1R3, taste receptors, umami taste
Publication Note: The publisher’s version of record is available at http://www.dx.doi.org/10.1523/JNEUROSCI.3356-15.2016
Persistent Link to This Record: http://purl.flvc.org/fsu/fd/FSU_libsubv1_wos_000368348100014
Host Institution: FSU
Is Part Of: Journal of Neuroscience.
0270-6474
Issue: iss. 1, vol. 36

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Schier, L. A., & Spector, A. C. (2016). Behavioral Evidence for More than One Taste Signaling Pathway for Sugars in Rats. Journal Of Neuroscience. Retrieved from http://purl.flvc.org/fsu/fd/FSU_libsubv1_wos_000368348100014