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L-Citrulline supplementation attenuates blood pressure, wave reflection and arterial stiffness responses to metaboreflex and cold stress in overweight men

Title: L-Citrulline supplementation attenuates blood pressure, wave reflection and arterial stiffness responses to metaboreflex and cold stress in overweight men.
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Name(s): Figueroa, Arturo, author
Alvarez-Alvarado, Stacey, author
Jaime, Salvador J., author
Kalfon, Roy, author
Type of Resource: text
Genre: Text
Date Issued: 2016-07-28
Physical Form: computer
online resource
Extent: 1 online resource
Language(s): English
Abstract/Description: Combined isometric exercise or metaboreflex activation (post-exercise muscle ischaemia (PEMI)) and cold pressor test (CPT) increase cardiac afterload, which may lead to adverse cardiovascular events. l-Citrulline supplementation (l-CIT) reduces systemic arterial stiffness (brachial-ankle pulse wave velocity (baPWV)) at rest and aortic haemodynamic responses to CPT. The aim of this study was to determine the effect of l-CIT on aortic haemodynamic and baPWV responses to PEMI+CPT. In all, sixteen healthy, overweight/obese males (age 24 (sem 6) years; BMI 293 (sem 40) kg/m(2)) were randomly assigned to placebo or l-CIT (6 g/d) for 14 d in a cross-over design. Brachial and aortic systolic blood pressure (SBP), diastolic blood pressure (DBP) and mean arterial pressure (MAP), aortic augmented pressure (AP), augmentation index (AIx), baPWV, reflection timing (Tr) and heart rate (HR) were evaluated at rest and during isometric handgrip exercise (IHG), PEMI and PEMI+CPT at baseline and after 14 d. No significant effects were evident after l-CIT at rest. l-CIT attenuated the increases in aortic SBP and wave reflection (AP and AIx) during IHG, aortic DBP, MAP and AIx during PEMI, and aortic SBP, DBP, MAP, AP, AIx and baPWV during PEMI+CPT compared with placebo. HR and Tr were unaffected by l-CIT in all conditions. Our findings demonstrate that l-CIT attenuates aortic blood pressure and wave reflection responses to exercise-related metabolites. Moreover, l-CIT attenuates the exaggerated arterial stiffness response to combined metaboreflex activation and cold exposure, suggesting a protective effect against increased cardiac afterload during physical stress.
Identifier: FSU_libsubv1_wos_000379136100008 (IID), 10.1017/S0007114516001811 (DOI)
Keywords: Aortic blood pressure, aortic hemodynamic-responses, Arterial stiffness, augmentation index, Cold pressor test, handgrip exercise, heart-failure patients, hypertensive humans, Isometric exercise, isometric-exercise, l-Citrulline supplementation, Metaboreflex activation, muscle metaboreflex, oral supplementation, postmenopausal women, watermelon supplementation, Wave reflection
Publication Note: The publisher’s version of record is available at http://www.dx.doi.org/10.1017/S0007114516001811
Persistent Link to This Record: http://purl.flvc.org/fsu/fd/FSU_libsubv1_wos_000379136100008
Owner Institution: FSU
Is Part Of: British Journal of Nutrition.
0007-1145
Issue: iss. 2, vol. 116

Choose the citation style.
Figueroa, A., Alvarez-Alvarado, S., Jaime, S. J., & Kalfon, R. (2016). L-Citrulline supplementation attenuates blood pressure, wave reflection and arterial stiffness responses to metaboreflex and cold stress in overweight men. British Journal Of Nutrition. Retrieved from http://purl.flvc.org/fsu/fd/FSU_libsubv1_wos_000379136100008