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Evidence for a Proapoptotic Role of Matrix Metalloproteinase-26 in Human Prostate Cancer Cells and Tissues

Title: Evidence for a Proapoptotic Role of Matrix Metalloproteinase-26 in Human Prostate Cancer Cells and Tissues.
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Name(s): Khamis, Zahraa I., author
Iczkowski, Kenneth A., author
Man, Yan-Gao, author
Bou-Dargham, Mayassa J., author
Sang, Qing-Xiang Amy, author
Type of Resource: text
Genre: Text
Date Issued: 2016
Physical Form: computer
online resource
Extent: 1 online resource
Language(s): English
Abstract/Description: Matrix metalloproteinases (MMPs) play intricate roles in cancer progression; some promote invasion and angiogenesis while others suppress tumor growth. For example, human MMP-26/endometase/matrilysin-2 was reported to be either protective or pro-tumorigenic. Our previous reports suggested pro-invasion and anti-inflammation properties in prostate cancer. Here, we provide evidence for a protective role of MMP-26 in the prostate. MMP-26 expression levels in androgen-repressed human prostate cancer (ARCaP) cells, transfected with sense or anti-sense MMP-26 cDNA, are directly correlated with those of the pro-apoptotic marker Bax. Immunohistochemical staining of prostate cancer tissue samples shows similar protein expression patterns, correlating the expression levels of MMP-26 and Bax in benign, neoplastic, and invasive prostate cancer tissues. The MMP-26 protein levels were upregulated in high grade prostate intraepithelial neoplasia (HGPIN) and decreased during the course of disease progression. Further analysis using an indirect terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) assay showed that many tumor cells expressing MMP-26 were undergoing apoptosis. This study showed that the high level of MMP-26 expression is positively correlated with the presence of apoptotic cells. This pro-apoptotic role of MMP-26 in human prostate cancer cells and tissues may enhance our understanding of the paradoxical roles of MMP-26 in tumor invasion and progression.
Identifier: FSU_libsubv1_wos_000366281500011 (IID), 10.7150/jca.13067 (DOI)
Keywords: and cancer progression, apoptosis, Bax, beta, carcinoma, Endometase, expression, fas ligand, inhibitors, matrilysin-2, matrix metalloproteinases, mmp-26, promotes invasion, prostate, protective role, receptor, tumor-cells, tumorigenic
Publication Note: The publisher’s version of record is available at http://www.dx.doi.org/10.7150/jca.13067
Persistent Link to This Record: http://purl.flvc.org/fsu/fd/FSU_libsubv1_wos_000366281500011
Owner Institution: FSU
Is Part Of: Journal of Cancer.
1837-9664
Issue: iss. 1, vol. 7

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Khamis, Z. I., Iczkowski, K. A., Man, Y. -G., Bou-Dargham, M. J., & Sang, Q. -X. A. (2016). Evidence for a Proapoptotic Role of Matrix Metalloproteinase-26 in Human Prostate Cancer Cells and Tissues. Journal Of Cancer. Retrieved from http://purl.flvc.org/fsu/fd/FSU_libsubv1_wos_000366281500011