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Multiparametric [F-18]Fluorodeoxyglucose/[F-18]Fluoromisonidazole Positron Emission Tomography/Magnetic Resonance Imaging of Locally Advanced Cervical Cancer for the Non-Invasive Detection of Tumor Heterogeneity

Title: Multiparametric [F-18]Fluorodeoxyglucose/[F-18]Fluoromisonidazole Positron Emission Tomography/Magnetic Resonance Imaging of Locally Advanced Cervical Cancer for the Non-Invasive Detection of Tumor Heterogeneity: A Pilot Study.
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Name(s): Pinker, Katja, author
Andrzejewski, Piotr, author
Baltzer, Pascal, author
Polanec, Stephan H., author
Sturdza, Alina, author
Georg, Dietmar, author
Helbich, Thomas H., author
Karanikas, Georgios, author
Grimm, Christoph, author
Polterauer, Stephan, author
Poetter, Richard, author
Wadsak, Wolfgang, author
Mitterhauser, Markus, author
Georg, Petra, author
Type of Resource: text
Genre: Text
Date Issued: 2016-05-11
Physical Form: computer
online resource
Extent: 1 online resource
Language(s): English
Abstract/Description: Objectives To investigate fused multiparametric positron emission tomography/magnetic resonance imaging (MP PET/MRI) at 3T in patients with locally advanced cervical cancer, using high-resolution T2-weighted, contrast-enhanced MRI (CE-MRI), diffusion-weighted imaging (DWI), and the radiotracers [F-18]fluorodeoxyglucose ([F-18]FDG) and [F-18]fluoromisonidazol ([F-18]FMISO) for the non-invasive detection of tumor heterogeneity for an improved planning of chemo-radiation therapy (CRT). Materials and Methods Sixteen patients with locally advanced cervix were enrolled in this IRB approved and were examined with fused MP [F-18]FDG/[F-18]FMISO PET/MRI and in eleven patients complete data sets were acquired. MP PET/MRI was assessed for tumor volume, enhancement (EH)-kinetics, diffusivity, and [F-18]FDG/[F-18]FMISO-avidity. Descriptive statistics and voxel-by-voxel analysis of MRI and PET parameters were performed. Correlations were assessed using multiple correlation analysis. Results All tumors displayed imaging parameters concordant with cervix cancer, i.e. type II/III EH-kinetics, restricted diffusivity (median ADC 0.80x10(-3)mm(2)/sec), [F-18]FDG-(median SUV(max)16.2) and [F-18]FMISO-avidity (median SUV(max)3.1). In all patients, [F-18]FMISO PET identified the hypoxic tumor subvolume, which was independent of tumor volume. A voxel-by-voxel analysis revealed only weak correlations between the MRI and PET parameters (0.05-0.22), indicating that each individual parameter yields independent information and the presence of tumor heterogeneity. Conclusion
Identifier: FSU_libsubv1_wos_000376587300065 (IID), 10.1371/journal.pone.0155333 (DOI)
Keywords: carcinoma, fdg-pet, gynecologic malignancies, Hypoxia, MRI, pimonidazole, predictive assay, radiation-therapy, radiotherapy, uterine cervix
Publication Note: The publisher’s version of record is available at http://www.dx.doi.org/10.1371/journal.pone.0155333
Persistent Link to This Record: http://purl.flvc.org/fsu/fd/FSU_libsubv1_wos_000376587300065
Owner Institution: FSU
Is Part Of: Plos One.
1932-6203
Issue: iss. 5, vol. 11

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Pinker, K., Andrzejewski, P., Baltzer, P., Polanec, S. H., Sturdza, A., Georg, D., … Georg, P. (2016). Multiparametric [F-18]Fluorodeoxyglucose/[F-18]Fluoromisonidazole Positron Emission Tomography/Magnetic Resonance Imaging of Locally Advanced Cervical Cancer for the Non-Invasive Detection of Tumor Heterogeneity: A Pilot Study. Plos One. Retrieved from http://purl.flvc.org/fsu/fd/FSU_libsubv1_wos_000376587300065