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The Effect of Casein Protein Prior to Sleep on Fat Metabolism in Obese Men

Title: The Effect of Casein Protein Prior to Sleep on Fat Metabolism in Obese Men.
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Name(s): Kinsey, Amber W., author
Cappadona, Stacy R., author
Panton, Lynn B., author
Allman, Brittany R., author
Contreras, Robert J., author
Hickner, Robert C., author
Ormsbee, Michael J., author
Type of Resource: text
Genre: Text
Date Issued: 2016-08
Physical Form: computer
online resource
Extent: 1 online resource
Language(s): English
Abstract/Description: We have previously shown that ingesting protein at night before sleep is either beneficial or non-detrimental to metabolism, health, and body composition in obese women. However, the overnight protein-induced lipolytic actions and mechanism for improved metabolism and body composition have not been fully established. Therefore, in a crossover design, twelve obese men (age, 27.0 +/- 2.2 years) were randomly assigned to ingest (within 30 min of sleep) casein protein (CAS, 120 kcal) or a non-nutritive placebo (PLA) before going to sleep. Markers of fat metabolism (lipolysis, substrate utilization, growth hormone), insulin, glucose, resting energy expenditure (REE), and appetite (questionnaire and ghrelin) were measured. During sleep and the next morning, interstitial glycerol from the subcutaneous abdominal adipose tissue (SCAAT) was measured using microdialysis. There were no differences in SCAAT glycerol (overnight: CAS, 177.4 +/- 26.7; PLA, 183.8 +/- 20.2 mu mol/L; morning: CAS, 171.6 +/- 19.1; PLA, 161.5 +/- 18.6 mu mol/L), substrate utilization, REE, or any blood markers between CAS and PLA. Desire to eat was greater for CAS compared to baseline (p = 0.03), but not different from PLA (baseline: 39 +/- 6, CAS: 62 +/- 8, PLA: 55 +/- 5 mm). CAS consumption before sleep did not affect fat or glucose metabolism, REE, or suppress appetite in hyperinsulemic obese men. CAS may be consumed before sleep without impeding overnight or morning fat metabolism in young, obese men.
Identifier: FSU_libsubv1_wos_000380766500008 (IID), 10.3390/nu8080452 (DOI)
Keywords: adipose-tissue lipolysis, appetite, blood-flow changes, cardiometabolic risk, casein, energy-expenditure, food-intake, healthy-young men, insulin-resistance, microdialysis, milk-proteins, nighttime eating, obesity, skeletal-muscle, sleep, weight-gain
Publication Note: The publisher’s version of record is available at http://www.dx.doi.org/10.3390/nu8080452
Persistent Link to This Record: http://purl.flvc.org/fsu/fd/FSU_libsubv1_wos_000380766500008
Host Institution: FSU
Is Part Of: Nutrients.
2072-6643
Issue: iss. 8, vol. 8

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Kinsey, A. W., Cappadona, S. R., Panton, L. B., Allman, B. R., Contreras, R. J., Hickner, R. C., & Ormsbee, M. J. (2016). The Effect of Casein Protein Prior to Sleep on Fat Metabolism in Obese Men. Nutrients. Retrieved from http://purl.flvc.org/fsu/fd/FSU_libsubv1_wos_000380766500008