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Molecular signatures associated with ZIKV exposure in human cortical neural progenitors

Title: Molecular signatures associated with ZIKV exposure in human cortical neural progenitors.
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Name(s): Zhang, Feiran, author
Hammack, Christy, author
Ogden, Sarah C., author
Cheng, Yichen, author
Lee, Emily M., author
Wen, Zhexing, author
Qian, Xuyu, author
Nguyen, Ha Nam, author
Li, Yujing, author
Yao, Bing, author
Xu, Miao, author
Xu, Tianlei, author
Chen, Li, author
Wang, Zhiqin, author
Feng, Hao, author
Huang, Wei-Kai, author
Yoon, Ki-jun, author
Shan, Chao, author
Huang, Luoxiu, author
Qin, Zhaohui, author
Christian, Kimberly M., author
Shi, Pei-Yong, author
Xu, Mingjiang, author
Xia, Menghang, author
Zheng, Wei, author
Wu, Hao, author
Song, Hongjun, author
Tang, Hengli, author
Ming, Guo-Li, author
Jin, Peng, author
Type of Resource: text
Genre: Text
Date Issued: 2016-10-14
Physical Form: computer
online resource
Extent: 1 online resource
Language(s): English
Abstract/Description: Zika virus (ZIKV) infection causes microcephaly and has been linked to other brain abnormalities. How ZIKV impairs brain development and function is unclear. Here we systematically profiled transcriptomes of human neural progenitor cells exposed to Asian ZIKV(C), African ZIKV(M), and dengue virus (DENV). In contrast to the robust global transcriptome changes induced by DENV, ZIKV has a more selective and larger impact on expression of genes involved in DNA replication and repair. While overall expression profiles are similar, ZIKV(C), but not ZIKV(M), induces upregulation of viral response genes and TP53. P53 inhibitors can block the apoptosis induced by both ZIKV(C) and ZIKV(M) in hNPCs, with higher potency against ZIKV(C)-induced apoptosis. Our analyses reveal virus- and strain-specific molecular signatures associated with ZIKV infection. These datasets will help to investigate ZIKV-host interactions and identify neurovirulence determinants of ZIKV.
Identifier: FSU_libsubv1_wos_000386945000012 (IID), 10.1093/nar/gkw765 (DOI)
Keywords: apoptosis, cells, expression, gene, induced hemorrhage, inhibitor, mouse model, organoids, p53, virus capsid protein
Publication Note: The publisher’s version of record is available at http://www.dx.doi.org/10.1093/nar/gkw765
Persistent Link to This Record: http://purl.flvc.org/fsu/fd/FSU_libsubv1_wos_000386945000012
Owner Institution: FSU
Is Part Of: Nucleic Acids Research.
0305-1048
Issue: iss. 18, vol. 44

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Zhang, F., Hammack, C., Ogden, S. C., Cheng, Y., Lee, E. M., Wen, Z., … Jin, P. (2016). Molecular signatures associated with ZIKV exposure in human cortical neural progenitors. Nucleic Acids Research. Retrieved from http://purl.flvc.org/fsu/fd/FSU_libsubv1_wos_000386945000012