You are here

In search of the perfect phenotype

Title: In search of the perfect phenotype: an analysis of linkage and association studies of reading and reading-related processes.
30 views
7 downloads
Name(s): Skiba, Thomas, author
Landi, Nicole, author
Wagner, Richard, author
Grigorenko, Elena L, author
Type of Resource: text
Genre: Text
Date Issued: 2011-01-01
Physical Form: computer
online resource
Extent: 1 online resource
Language(s): English
Abstract/Description: Reading ability and specific reading disability (SRD) are complex traits involving several cognitive processes and are shaped by a complex interplay of genetic and environmental forces. Linkage studies of these traits have identified several susceptibility loci. Association studies have gone further in detecting candidate genes that might underlie these signals. These results have been obtained in samples of mainly European ancestry, which vary in their languages, inclusion criteria, and phenotype assessments. Such phenotypic heterogeneity across samples makes understanding the relationship between reading (dis)ability and reading-related processes and the genetic factors difficult; in addition, it may negatively influence attempts at replication. In moving forward, the identification of preferable phenotypes for future sample collection may improve the replicability of findings. This review of all published linkage and association results from the past 15 years was conducted to determine if certain phenotypes produce more replicable and consistent results than others.
Identifier: FSU_pmch_21243420 (IID), 10.1007/s10519-011-9444-7 (DOI), PMC3056345 (PMCID), 21243420 (RID), 21243420 (EID)
Grant Number: DC007665, HD052120, P50 HD052120, P50 HD052120-03, P50 HD052120-04, R01 DC007665, R01 DC007665-05, R01 TW008274, R01 TW008274-03, TW008274
Publication Note: This NIH-funded author manuscript originally appeared in PubMed Central at http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3056345.
Subject(s): Achievement
Attention Deficit Disorder with Hyperactivity/diagnosis
Attention Deficit Disorder with Hyperactivity/genetics
Attention Deficit Disorder with Hyperactivity/psychology
Child
Comorbidity
Cross-Cultural Comparison
Diseases in Twins/diagnosis
Diseases in Twins/genetics
Diseases in Twins/psychology
Dyslexia/genetics
Dyslexia/psychology
Education, Special
Genetic Association Studies
Genetic Linkage
Genotype
Humans
Intelligence/genetics
Lod Score
Mental Recall
Microsatellite Repeats
Neuropsychological Tests
Phenotype
Phonetics
Verbal Learning
Persistent Link to This Record: http://purl.flvc.org/fsu/fd/FSU_pmch_21243420
Owner Institution: FSU
Is Part Of: Behavior genetics.
1573-3297
Issue: iss. 1, vol. 41

Choose the citation style.
Skiba, T., Landi, N., Wagner, R., & Grigorenko, E. L. (2011). In search of the perfect phenotype: an analysis of linkage and association studies of reading and reading-related processes. Behavior Genetics. Retrieved from http://purl.flvc.org/fsu/fd/FSU_pmch_21243420