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At the height of fashion

Title: At the height of fashion: what genetics can teach us about neurodevelopmental disabilities.
Name(s): Grigorenko, Elena L, author
Type of Resource: text
Genre: Text
Date Issued: 2009-04-01
Physical Form: computer
online resource
Extent: 1 online resource
Language(s): English
Abstract/Description: The last decade has generated much interest in the genetics of developmental disorders. This interest, in part, is focused on two issues: the specificity/generality and the type/frequency of the genetic mechanisms involved. First, it appears that studies are more fruitful and their results more replicable, broadly speaking, when they conceptualize disorders not holistically, as categorical units, but componentially, through various quantitative processes. Second, there have been several successful investigations of severe impairments in a number of isolated families with higher than typical frequencies of developmental disorders. Yet, it has been difficult to generalize the genetic mechanisms involved in these rare cases to the general population. Current findings suggest the involvement of multiple genetic mechanisms in the manifestations of childhood-onset conditions. It is possible that each 'facet' (or component) of a disorder is controlled by a semi-independent set of genes. Numerous components appear to be deficient in more than one disorder, possibly explaining comorbidity. The genetic foundation of developmental disorders may be formed not by isolated genes, but rather by a combination of genes and the pathways that these genes regulate. These accumulating findings have direct implications for designing both diagnostic and treatment approaches to childhood-onset disorders.
Identifier: FSU_pmch_19532035 (IID), 10.1097/WCO.0b013e3283292414 (DOI), PMC2891771 (PMCID), 19532035 (RID), 19532035 (EID), 00019052-200904000-00003 (PII)
Grant Number: P0 HD052120, P50 HD052120, P50 HD052120-040004, R01 DC007665, R01 DC007665, R01 DC007665-05
Publication Note: This NIH-funded author manuscript originally appeared in PubMed Central at
Subject(s): Child
Developmental Disabilities/genetics
Persistent Link to This Record:
Host Institution: FSU
Is Part Of: Current opinion in neurology.
Issue: iss. 2, vol. 22

Choose the citation style.
Grigorenko, E. L. (2009). At the height of fashion: what genetics can teach us about neurodevelopmental disabilities. Current Opinion In Neurology. Retrieved from