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Process Improvement of Rac-Progesterone and Other Synthetic Studies

Title: Process Improvement of Rac-Progesterone and Other Synthetic Studies.
Name(s): Slegeris, Rimantas, author
Dudley, Gregory B., professor directing dissertation
Telotte, John C., university representative
McQuade, D. Tyler (David Tyler), committee member
Saha, Sourav, committee member
Shatruk, Mykhailo, committee member
Florida State University, degree granting institution
College of Arts and Sciences, degree granting college
Department of Chemistry and Biochemistry, degree granting department
Type of Resource: text
Genre: Text
Issuance: monographic
Date Issued: 2015
Publisher: Florida State University
Place of Publication: Tallahassee, Florida
Physical Form: computer
online resource
Extent: 1 online resource (194 pages)
Language(s): English
Abstract/Description: This thesis describes the work performed by the author during PhD studies at FSU. The first two chapters present the summary of the studies done trying to accomplish the first total synthesis of aldingenin B - a natural product first isolated in 2003. While our studies were ongoing, some additional information on the structure of the natural product emerged, therefore our studies and their relationship with the literature available up to 2015 are discussed in detail. Chapters 3 through 6 represent the main topic of the thesis. They focus on the studies directed towards the development of the efficient synthesis of ent-progesterone - a potential drug candidate for the treatment of traumatic brain injury. Chapter 3 introduces the problem and the necessity for such synthesis and reviews the literature relevant to the topic. Chapter 4 presents an improved synthesis of rac-progesterone - an important step in the synthesis of ent-progesterone. Chapter 5 compares the efficiency of the two approaches: an old one and the improved route.
Identifier: FSU_2015fall_Slegeris_fsu_0071E_12550 (IID)
Submitted Note: A Dissertation submitted to the Department of Chemistry and Biochemistry in partial fulfillment of the Doctor of Philosophy.
Degree Awarded: Spring Semester 2015.
Date of Defense: April 29, 2015.
Keywords: aldingenin B, benzylation, ent-progesterone, process improvement, progesterone, total synthesis
Bibliography Note: Includes bibliographical references.
Advisory Committee: Gregory B. Dudley, Professor Directing Dissertation; John Telotte, University Representative; Tyler McQuade, Committee Member; Sourav Saha, Committee Member; Michael Shatruk, Committee Member.
Subject(s): Chemistry, Organic
Persistent Link to This Record:
Owner Institution: FSU

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Slegeris, R. (2015). Process Improvement of Rac-Progesterone and Other Synthetic Studies. Retrieved from