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Afferent Circuitry of the Ventromedial Hypothalamus and Its Activation in Paternal Behavior of the Socially Monogamous Prairie Vole

Title: The Afferent Circuitry of the Ventromedial Hypothalamus and Its Activation in Paternal Behavior of the Socially Monogamous Prairie Vole.
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Name(s): Rogers, Richard S., author
Department of Chemistry and Biochemistry
Type of Resource: text
Genre: Text
Issuance: monographic
Date Issued: 2015
Physical Form: computer
online resource
Extent: 1 online resource
Language(s): English
Abstract/Description: Paternal behavior is an interesting and important research topic due to its integral contribution to the fitness and well-being of multiple species, including humans. Although paternal behavior is well described in literature, attempts at neurobiological characterization have yielded conflicting results that fail to address brain region interconnectivity. This study was designed to evaluate the relationship between afferent VMH circuitry and the onset of paternal behavior, using the prairie vole (Microtus ochrogaster) model. Sexually naïve male prairie voles received injections of the retrograde neurotracer Fluoro-Gold (FG), into the VMH. Two weeks later, subjects were exposed to either conspecific pups, contained within a tea-ball, or an empty tea-ball (control) for 1 hr. Immunohistochemical labeling was conducted for both FG and the neuronal activity marker Egr-1, in order to evaluate neuronal and afferent pathway activation between the ventromedial hypothalamus (VMH) and the amygdala (AMYG), bed nucleus of the stria terminalis (BNST), lateral septum (LS) and ventral tegmental area (VTA). Similar to the pathway implicated in the onset of maternal behavior, the results of this study showed pup exposure-induced neuronal activation in the AMYG and BNST, particularly in the efferent pathways from these two brain areas to the VMH. This effect was not found in the LS and VTA projection neurons to the VMH. Together, the data suggests a brain region-specific neuronal activation by pup exposure in particular brain circuitry, implicating its possible involvement in paternal behavior.
Identifier: FSU_migr_uhm-0545 (IID)
Keywords: Biochemistry, Neuroscience, Psychology, Paternal Behavior, Parental Behavior, Fatherhood, Ventromedial Hypothalamus, Vole
Submitted Note: A Thesis submitted to the Department of Biochemistry in partial fulfillment of the requirements for graduation with Honors in the Major.
Degree Awarded: Summer Semester, 2015.
Subject(s): Behavior
Neuropsychology
Psychobiology
Human behavior
Biochemistry
Brain chemistry
Neurochemistry
Neurobiology
Neurosciences
Persistent Link to This Record: http://purl.flvc.org/fsu/fd/FSU_migr_uhm-0545
Owner Institution: FSU
Is Part of Series: Honors Theses.

Choose the citation style.
Rogers, R. S. (2015). The Afferent Circuitry of the Ventromedial Hypothalamus and Its Activation in Paternal Behavior of the Socially Monogamous Prairie Vole. Retrieved from http://purl.flvc.org/fsu/fd/FSU_migr_uhm-0545