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Social and Parental Experience Affects Histone H3 Acetylation in the Prairie Vole Brain

Title: Social and Parental Experience Affects Histone H3 Acetylation in the Prairie Vole Brain.
Name(s): Eastham, Patrick, author
Department of Psychology
Type of Resource: text
Genre: Text
Issuance: monographic
Date Issued: 2015
Physical Form: computer
online resource
Extent: 1 online resource
Language(s): English
Abstract/Description: The present study investigated the possible relationship between parental experience and expression of acetylated histone H3 in various brain regions associated with parental behavior in male and female prairie voles (Michrotus Ochrogaster). Acetylated histone H3 immunoreactive (acH3-ir) neurons were visualized by immunocytochemical procedure and DAB stain. I found that females had higher acH3-ir expression than males in the ventral part of the lateral septum and ventral tegmental area (VTA), parental voles had decreased and increased expression compared to sexually naïve voles in the cortical amygdala (CoA) and VTA, respectively, and there was only a single region that showed interaction effects, the VTA, where female parents had increased expression compared to all other groups. The present findings, when observed in the context of the approach-avoidance behavioral model, suggest that the decrease in DNA accessibility from lower acetylation of H3 in the CoA leads to the expression of parental behavior through a decrease in avoidance tendencies while the increase in DNA accessibility from higher acetylation of H3 in the VTA leads to the expression of maternal behavior through an increase in approach tendencies. To control for total histone expression, histone H1 was also measured and non-significance differences in H1 levels support the conclusions drawn from the acH3-ir data. Future experiments should include neuronal phenotyping via double labeling, anterograde axonal tracing, and HDAC pharmacological manipulation in order to establish any causal relationship from the preliminary correlational relationships seen in this thesis.
Identifier: FSU_migr_uhm-0516 (IID)
Keywords: Neuroscience, Epigenetics, Parental, Behavior
Submitted Note: A Thesis submitted to the Department of Psychology in partial fulfillment of the requirements for graduation with Honors in the Major.
Degree Awarded: Spring Semester, 2015.
Subject(s): Psychobiology
Persistent Link to This Record:
Owner Institution: FSU
Is Part of Series: Honors Theses.

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Eastham, P. (2015). Social and Parental Experience Affects Histone H3 Acetylation in the Prairie Vole Brain. Retrieved from