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Does Baseline HDL-C Influence the Dose and Response Relationship Between Acute Exercise and Post-Exercise HDL-C Improvement?

Title: Does Baseline HDL-C Influence the Dose and Response Relationship Between Acute Exercise and Post-Exercise HDL-C Improvement?.
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Name(s): Lawrence, Tait, author
Moffatt, Robert J., professor directing thesis
Panton, Lynn B., committee member
Grubbs, Laurie M., committee member
Department of Nutrition, Food, and Exercise Science, degree granting department
Florida State University, degree granting institution
Type of Resource: text
Genre: Text
Issuance: monographic
Date Issued: 2008
Publisher: Florida State University
Place of Publication: Tallahassee, Florida
Physical Form: computer
online resource
Extent: 1 online resource
Language(s): English
Abstract/Description: Does Baseline HDL-C Influence the Dose and Response Relationship Between Acute Exercise and Post-exercise HDL-C Improvement? Purpose: The purpose of this study was to determine if high density lipoprotein cholesterol (HDL-C) status (low vs. normal) affects the magnitude of post-exercise HDL-C changes over a 24 hour period and whether different caloric expenditures (300, 500 and 700 kcals) augment this relationship. Methods: Two groups of healthy untrained male volunteers participated in this study. Subjects were assigned to one of two groups based upon their resting HDL-C level. The LOW HDL-C group consisted of 13 subjects with clinically low HDL-C (< 40mg/dl) and the NORMAL HDL-C group consisted of 14 subjects with normal HDL-C (≥ 45mg/dl). Age, diet, VO2max and anthropometric data were collected prior to initiation of the experimental protocol and were similar for both groups. The characteristics of the LOW group were 21.9 ± 2.0 yrs of age, 1.8 ± 0.1 m tall, weighed 80.9 ± 7.9 kg, and had a BMI of 25.2 ± 2.2 kg/m2, a VO2max of 45.8 ± 5.1 ml/kg/min and a resting HDL-C of 35.7 ± 2.7 mg/dl. Characteristics of the NORMAL group were 23.4 ± 7.1yrs of age, 1.8 ± 0.1 m tall, weighed 78.6 ± 7.6 kg, and had a BMI of 24.3 ± 2.5 kg/m2, a VO2max of 47.5 ± 4.8 ml/kg/min and a resting HDL-C of 53.9 ± 5.8 mg/dl. Subjects randomly completed three nonconsecutive exercise trials (300, 500, and 700 kcals) on a treadmill at 65% of VO2max. Blood samples were collected pre-exercise (PRE), immediately post-exercise (IP), and 24 hours post-exercise (+24). Each sample was analyzed for HDL-C and its subfractions (HDL2-C and HDL3-C) and was corrected for plasma volume shifts. Results: There was no significant main effect of group or condition (kcal expenditure) and no interactions among variables. HDL3-C increased significantly IP regardless of group or caloric expenditure, but was not different from PRE at +24. HDL-C increased (5.6%) significantly IP regardless of group when the 500 and 700 kcal trials were combined, again the effect was transient. Individually, no caloric expenditure produced HDL-C or subfraction changes that were significantly different from one another. Conclusions: Baseline HDL-C status had no significant effect on the magnitude of post-exercise HDLC alterations. Furthermore, post-exercise improvements of HDL-C in untrained men occur via increases in HDL3-C and primarily at caloric expenditures above 300 kcal
Identifier: FSU_migr_etd-3249 (IID)
Submitted Note: A Thesis submitted to the Department of Nutrition, Food and Exercise Sciences in partial fulfillment of the requirements for the degree of Master of Science.
Degree Awarded: Fall Semester, 2008.
Date of Defense: October 7, 2008.
Keywords: Blood Lipids, High Density Lipoprotein, Acute Exercise, Cholesterol
Bibliography Note: Includes bibliographical references.
Advisory Committee: Robert J. Moffatt, Professor Directing Thesis; Lynn B. Panton, Committee Member; Laurie M. Grubbs, Committee Member.
Subject(s): Food
Persistent Link to This Record: http://purl.flvc.org/fsu/fd/FSU_migr_etd-3249
Owner Institution: FSU

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Lawrence, T. (2008). Does Baseline HDL-C Influence the Dose and Response Relationship Between Acute Exercise and Post-Exercise HDL-C Improvement? Retrieved from http://purl.flvc.org/fsu/fd/FSU_migr_etd-3249