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Efficacy of Dried Plum in Modulting Biomarkers of Bone Turnover in Postmenopausal Women

Title: The Efficacy of Dried Plum in Modulting Biomarkers of Bone Turnover in Postmenopausal Women.
Name(s): Saadat, Raz L., author
Arjmandi, Bahram H., professor directing thesis
Spicer, Maria, committee member
Tenenbaum, Gershon, committee member
Department of Nutrition, Food, and Exercise Science, degree granting department
Florida State University, degree granting institution
Type of Resource: text
Genre: Text
Issuance: monographic
Date Issued: 2010
Publisher: Florida State University
Place of Publication: Tallahassee, Florida
Physical Form: computer
online resource
Extent: 1 online resource
Language(s): English
Abstract/Description: Previous studies from our lab suggest that dried plum may exert positive effects on biomarkers of bone turnover in animal studies and a short-term clinical trial. Dried plum is not only a rich source of vitamins, minerals and polyphenols, but has been reported as having high antioxidant properties that may be responsible in prevention of bone loss. The purpose of this study was to examine the effect of three-month dried plum consumption on the biomarkers of bone turnover in postmenopausal women. A total of 123 postmenopausal women experiencing mild bone loss and who were free of hormone replacement therapy were randomly assigned to consume either 100 grams of dried plum or a nutritional equivalence of dried apple for three consecutive months. Bone-specific alkaline phosphatase (B-SAP), osteocalcin (OC), tartrate-resistant acid phosphatase-5b (TRAP5b), and deoxypyridinoline (Dpd) were analyzed at baseline and after three months to test the effect of daily consumption of dried plum on bone turnover markers. Repeated measures (RM) multiple analysis of variance (ANOVA) followed by RM ANOVA were conducted to analyze the results. Findings of this study indicated no significant differences between the dried plum and dried apple groups when the data were analyzed considering treatment by time interaction. However, treatment by dried plum increased Dpd, while time decreased TRAP5b and increased OC in the dried plum group. The inconsistency between markers of resorption, Dpd and TRAP5b, as well as discrepancies between our findings and previous studies suggests that blood and serum markers cannot be used to predict the effect of dried plum on bone density unless bone mineral density (BMD) is measured as the end point variable that would require study duration of at least six months and preferably longer.
Identifier: FSU_migr_etd-2143 (IID)
Submitted Note: A Thesis submitted to the Department of Nutrition, Food and Exercise Sciences in partial fulfillment of the requirements for the degree of Master of Science.
Degree Awarded: Spring Semester, 2010.
Date of Defense: March 5, 2010.
Keywords: Dried Plum, Bone, Women, Osteoporosis
Bibliography Note: Includes bibliographical references.
Advisory Committee: Bahram H. Arjmandi, Professor Directing Thesis; Maria Spicer, Committee Member; Gershon Tenenbaum, Committee Member.
Subject(s): Food
Persistent Link to This Record:
Owner Institution: FSU

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Saadat, R. L. (2010). The Efficacy of Dried Plum in Modulting Biomarkers of Bone Turnover in Postmenopausal Women. Retrieved from