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Leptin, Adiponectin, and Insulin in Women with PCOS, and the Effects of Apple Polyphenols and Exercise

Title: Leptin, Adiponectin, and Insulin in Women with PCOS, and the Effects of Apple Polyphenols and Exercise.
Name(s): Bendor, Liran, author
Spicer, Maria, professor directing thesis
Overton, Mike, committee member
McGee, Dan, committee member
Department of Nutrition, Food, and Exercise Science, degree granting department
Florida State University, degree granting institution
Type of Resource: text
Genre: Text
Issuance: monographic
Date Issued: 2008
Publisher: Florida State University
Place of Publication: Tallahassee, Florida
Physical Form: computer
online resource
Extent: 1 online resource
Language(s): English
Abstract/Description: Purpose: The purposes of this study were (1) to determine the correlations of adiponectin, leptin, the adiponectin:leptin (A/L) ratio, insulin, BMI, glucose, insulin resistance index (HOMA-IR), and waist circumference in women with PCOS, and (2) to examine the effects of an 8 week supplement of 75 g of dried apples daily and twice a week moderate intensity resistance exercise on these parameters. Methods: Baseline data for 26 women diagnosed with PCOS were analyzed. Of these 26 subjects, 13 completed the intervention study. In a 2X2 factorial design using apples and exercise, 70 g Kellogg's Frosted Mini Wheats was used as the control for the dried apples since it contained similar amounts of fiber and energy. Exercise consisted of twice a week full body routines, using 3 sets of 12 repetitions maximum (12RM). SPSS for Windows, Version 15.0 software was utilized to calculate and determine descriptive statistics, t-tests, Pearson correlations, and one way ANOVA. Results: In subjects with a BMI > 25 (n=13), insulin, HOMA-IR, and leptin were significantly higher (p<0.05), while adiponectin and the A/L ratio were significantly (p<0.05) lower than in the subjects with a BMI < 25 (n=13). In the correlational analyses of the data for all subjects at baseline (n=26), results were as expected in accordance with the literature. Adiponectin and leptin were significantly negatively correlated, but this correlation did not persist after controlling for BMI. There was a trend (p=0.058) towards a negative relationship between the A/L ratio and HOMA-IR (n=26). When separated by BMI, this relationship was not significant in the lean group (BMI <25, n=13), but in the obese group (BMI>30, n=8), the A/L ratio and HOMA-IR were significantly negatively correlated (p=0.048). In the intervention study, fasting serum glucose increased from baseline to endpoint in the cereal groups with and without exercise. Conclusions: The lean women with PCOS in this study did not exhibit the expected negative relationship between A/L ratio and HOMA-IR, suggesting a possible genetic polymorphism in their adipocytes. In terms of the intervention, this study found that 75 grams of dried apples and moderate intensity resistance exercise twice a week did not have any significant effect on any of the parameters measured other than a rise in fasting blood glucose associated with cereal intake in this study group (n=13). More subjects are required to meet the effect size necessary to assess correlations with confidence as well as to determine if the interventions have an effect on the outcomes.
Identifier: FSU_migr_etd-1331 (IID)
Submitted Note: A Thesis submitted to the Department of Nutrition, Food and Exercise Sciences in partial fulfillment of the requirements for the degree of Master of Science.
Degree Awarded: Fall Semester, 2008.
Date of Defense: August 15, 2008.
Keywords: Lean PCOS, Apple Polyphenol, Polycystic Ovary Syndrome, Adiponectin to Leptin Ratio, Obese PCOS
Bibliography Note: Includes bibliographical references.
Advisory Committee: Maria Spicer, Professor Directing Thesis; Mike Overton, Committee Member; Dan McGee, Committee Member.
Subject(s): Nutrition
Persistent Link to This Record:
Owner Institution: FSU

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Bendor, L. (2008). Leptin, Adiponectin, and Insulin in Women with PCOS, and the Effects of Apple Polyphenols and Exercise. Retrieved from