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Genetic Association Between Personality and Major Depression or Bipolar Disorder. A Polygenic Score Analysis Using Genome-wide Association Data

Title: The Genetic Association Between Personality and Major Depression or Bipolar Disorder. A Polygenic Score Analysis Using Genome-wide Association Data.
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Name(s): Middeldorp, C., author
de Moor, Marleen, author
McGrath, L., author
Gordon, S., author
Blackwood, D., author
Costa, Paul, author
Terracciano, Antonio, author
Krueger, Robert F., author
de Geus, Eco, author
Nyholt, Dale, author
Tanaka, Toshiko, author
Esko, Tönu, author
Madden, P., author
Derringer, Jaime, author
Amin, Najaf, author
Willemsen, Gonneke, author
Hottenga, Jouke-Jan, author
Distel, M., author
Uda, Manuela, author
Sanna, Serena, author
Spinhoven, Philip, author
Hartman, Catherina, author
Ripke, S., author
Sullivan, P., author
Realo, Anu, author
Allik, Jüri, author
Heath, Andrew, author
Pergadia, M., author
Agrawal, Arpana, author
Lin, Peng, author
Grucza, Richard, author
Widen, Elisabeth, author
Cousminer, D., author
Eriksson, Johan, author
Palotie, Aarno, author
Barnett, J., author
Lee, P., author
Luciano, Michelle, author
Tenesa, A., author
Davies, Gail, author
Lopez, Lorna, author
Hansell, Narelle, author
Medland, Sarah, author
Ferrucci, Luigi, author
Schlessinger, David, author
Montgomery, G., author
Wright, Margeret, author
Aulchenko, Y., author
Janssens, A., author
Oostra, Ben A., 1946-, author
Metspalu, Andres, author
Abecasis, Gonçalo, author
Deary, Ian J., author
Räikkönen, K., author
Bierut, Laura, author
Martin, Nicholas G., author
Wray, N., author
van Duijn, Cornelia, author
Smoller, Jordan W., 1961-, author
Penninx, Brenda, author
Boomsma, Dorret, author
Type of Resource: text
Genre: Text
Issuance: serial
Date Issued: 2011
Physical Form: computer
online resource
Extent: 1 online resource
Language(s): English
Abstract/Description: The relationship between major depressive disorder (MDD) and bipolar disorder (BD) remains controversial. Previous research has reported differences and similarities in risk factors for MDD and BD, such as predisposing personality traits. For example, high neuroticism is related to both disorders, whereas openness to experience is specific for BD. This study examined the genetic association between personality and MDD and BD by applying polygenic scores for neuroticism, extraversion, openness to experience, agreeableness and conscientiousness to both disorders. Polygenic scores reflect the weighted sum of multiple single-nucleotide polymorphism alleles associated with the trait for an individual and were based on a meta-analysis of genome-wide association studies for personality traits including 13,835 subjects. Polygenic scores were tested for MDD in the combined Genetic Association Information Network (GAIN-MDD) and MDD2000+ samples (N=8921) and for BD in the combined Systematic Treatment Enhancement Program for Bipolar Disorder and Wellcome Trust Case-Control Consortium samples (N=6329) using logistic regression analyses. At the phenotypic level, personality dimensions were associated with MDD and BD. Polygenic neuroticism scores were significantly positively associated with MDD, whereas polygenic extraversion scores were significantly positively associated with BD. The explained variance of MDD and BD, ∼0.1%, was highly comparable to the variance explained by the polygenic personality scores in the corresponding personality traits themselves (between 0.1 and 0.4%). This indicates that the proportions of variance explained in mood disorders are at the upper limit of what could have been expected. This study suggests shared genetic risk factors for neuroticism and MDD on the one hand and for extraversion and BD on the other.
Identifier: FSU_migr_geriatrics_faculty_publications-0005-P (IID)
Keywords: Bipolar Disorder/genetics, depressive disorder, genome-wide association study, personality/genetics, multifactorial inheritance/genetics
Uncontrolled subjects: Adult, Aged, Bipolar Disorder, Depressive Disorder, Major, Female, Genome-Wide Association Study, Humans, Male, Meta-Analysis as Topic, Middle Aged, Multifactorial Inheritance, Personality, Personality Inventory, Registries
Note: Published online 2011 October 18 in Translational Psychiatry. doi: 10.1038/tp.2011.45.
Citation: Middeldorp CM, De Moor MHM, McGrath LM, Gordon SD, Blackwood DH, Costa PT, Terracciano A, Krueger RF, De Geus EJC, Nyholt DR, Tanaka T, Esko T, Madden PAF, Derringer J, Amin N, Willemsen G, Hottenga J-J, Distel MA, Uda M, Sanna S, Spinhoven P, Hartman CA, Ripke S, Sullivan PF, Realo A, Allik J, Heath AC, Pergadia ML, Agrawal A, Lin P, Grucza RA, Widen E, Cousminer DL, Eriksson JG, Palotie A, Barnett JH, Lee PH, Luciano M, Tenesa A, Davies G, Lopez LM, Hansell NK, Medland SE, Ferrucci L, Schlessinger D, Montgomery GW, Wright MJ, Aulchenko YS, Janssens ACJW, Oostra BA, Metspalu A, Abecasis GR, Deary IJ, Räikkönen K, Bierut LJ, Martin NG, Wray NR, Van Duijn CM, Smoller JW, Penninx BWJH, & Boomsma DI (2011). The genetic association between personality and major depression or bipolar disorder. A polygenic score analysis using genome-wide association data. Translational Psychiatry, 1, e50. doi: 10.1038/tp.2011.45
Subject(s): Genetics
Genomics
Medical sciences
Mental health
Links: http://dx.doi.org/10.1038/tp.2011.45
Persistent Link to This Record: http://purl.flvc.org/fsu/fd/FSU_migr_geriatrics_faculty_publications-0005-P
Owner Institution: FSU
Is Part of Series: Department of Geriatrics Faculty Publications.
Is Part Of: Translational Psychiatry.
Issue: 1

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Middeldorp, C., De Moor, M., McGrath, L., Gordon, S., Blackwood, D., Costa, P., … Boomsma, D. (2011). The Genetic Association Between Personality and Major Depression or Bipolar Disorder. A Polygenic Score Analysis Using Genome-wide Association Data. Translational Psychiatry. Retrieved from http://dx.doi.org/10.1038/tp.2011.45

Title: The Genetic Association Between Personality and Major Depression or Bipolar Disorder. A Polygenic Score Analysis Using Genome-wide Association Data.
Name(s): Middeldorp, C., author
de Moor, Marleen, author
McGrath, L., author
Gordon, S., author
Blackwood, D., author
Costa, Paul, author
Terracciano, Antonio, author
Krueger, Robert F., author
de Geus, Eco, author
Nyholt, Dale, author
Tanaka, Toshiko, author
Esko, Tönu, author
Madden, P., author
Derringer, Jaime, author
Amin, Najaf, author
Willemsen, Gonneke, author
Hottenga, Jouke-Jan, author
Distel, M., author
Uda, Manuela, author
Sanna, Serena, author
Spinhoven, Philip, author
Hartman, Catherina, author
Ripke, S., author
Sullivan, P., author
Realo, Anu, author
Allik, Jüri, author
Heath, Andrew, author
Pergadia, M., author
Agrawal, Arpana, author
Lin, Peng, author
Grucza, Richard, author
Widen, Elisabeth, author
Cousminer, D., author
Eriksson, Johan, author
Palotie, Aarno, author
Barnett, J., author
Lee, P., author
Luciano, Michelle, author
Tenesa, A., author
Davies, Gail, author
Lopez, Lorna, author
Hansell, Narelle, author
Medland, Sarah, author
Ferrucci, Luigi, author
Schlessinger, David, author
Montgomery, G., author
Wright, Margeret, author
Aulchenko, Y., author
Janssens, A., author
Oostra, Ben A., 1946-, author
Metspalu, Andres, author
Abecasis, Gonçalo, author
Deary, Ian J., author
Räikkönen, K., author
Bierut, Laura, author
Martin, Nicholas G., author
Wray, N., author
van Duijn, Cornelia, author
Smoller, Jordan W., 1961-, author
Penninx, Brenda, author
Boomsma, Dorret, author
Type of Resource: text
Genre: Text
Issuance: serial
Date Issued: 2011
Physical Form: computer
online resource
Extent: 1 online resource
Language(s): English
Abstract/Description: The relationship between major depressive disorder (MDD) and bipolar disorder (BD) remains controversial. Previous research has reported differences and similarities in risk factors for MDD and BD, such as predisposing personality traits. For example, high neuroticism is related to both disorders, whereas openness to experience is specific for BD. This study examined the genetic association between personality and MDD and BD by applying polygenic scores for neuroticism, extraversion, openness to experience, agreeableness and conscientiousness to both disorders. Polygenic scores reflect the weighted sum of multiple single-nucleotide polymorphism alleles associated with the trait for an individual and were based on a meta-analysis of genome-wide association studies for personality traits including 13,835 subjects. Polygenic scores were tested for MDD in the combined Genetic Association Information Network (GAIN-MDD) and MDD2000+ samples (N=8921) and for BD in the combined Systematic Treatment Enhancement Program for Bipolar Disorder and Wellcome Trust Case-Control Consortium samples (N=6329) using logistic regression analyses. At the phenotypic level, personality dimensions were associated with MDD and BD. Polygenic neuroticism scores were significantly positively associated with MDD, whereas polygenic extraversion scores were significantly positively associated with BD. The explained variance of MDD and BD, ∼0.1%, was highly comparable to the variance explained by the polygenic personality scores in the corresponding personality traits themselves (between 0.1 and 0.4%). This indicates that the proportions of variance explained in mood disorders are at the upper limit of what could have been expected. This study suggests shared genetic risk factors for neuroticism and MDD on the one hand and for extraversion and BD on the other.
Identifier: FSU_migr_geriatrics_faculty_publications-0005 (IID), 10.1038/tp.2011.45 (DOI)
Keywords: Bipolar Disorder/genetics, depressive disorder, genome-wide association study, personality/genetics, multifactorial inheritance/genetics
Uncontrolled subjects: Adult, Aged, Bipolar Disorder, Depressive Disorder, Major, Female, Genome-Wide Association Study, Humans, Male, Meta-Analysis as Topic, Middle Aged, Multifactorial Inheritance, Personality, Personality Inventory, Registries
Note: Published online 2011 October 18 in Translational Psychiatry. doi: 10.1038/tp.2011.45.
Citation: Middeldorp CM, De Moor MHM, McGrath LM, Gordon SD, Blackwood DH, Costa PT, Terracciano A, Krueger RF, De Geus EJC, Nyholt DR, Tanaka T, Esko T, Madden PAF, Derringer J, Amin N, Willemsen G, Hottenga J-J, Distel MA, Uda M, Sanna S, Spinhoven P, Hartman CA, Ripke S, Sullivan PF, Realo A, Allik J, Heath AC, Pergadia ML, Agrawal A, Lin P, Grucza RA, Widen E, Cousminer DL, Eriksson JG, Palotie A, Barnett JH, Lee PH, Luciano M, Tenesa A, Davies G, Lopez LM, Hansell NK, Medland SE, Ferrucci L, Schlessinger D, Montgomery GW, Wright MJ, Aulchenko YS, Janssens ACJW, Oostra BA, Metspalu A, Abecasis GR, Deary IJ, Räikkönen K, Bierut LJ, Martin NG, Wray NR, Van Duijn CM, Smoller JW, Penninx BWJH, & Boomsma DI (2011). The genetic association between personality and major depression or bipolar disorder. A polygenic score analysis using genome-wide association data. Translational Psychiatry, 1, e50. doi: 10.1038/tp.2011.45
Subject(s): Genetics
Genomics
Medical sciences
Mental health
Links: http://dx.doi.org/10.1038/tp.2011.45
Persistent Link to This Record: http://purl.flvc.org/fsu/fd/FSU_migr_geriatrics_faculty_publications-0005
Owner Institution: FSU
Is Part of Series: Department of Geriatrics Faculty Publications.
Is Part Of: Translational Psychiatry.
Issue: 1