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Glucagon-like Peptide 1 Receptors in Lateral Septum Affect Food Intake

Title: Glucagon-like Peptide 1 Receptors in Lateral Septum Affect Food Intake.
Name(s): Terrill, Sarah J., author
Williams, Diana L., professor directing thesis
Spector, Alan C., committee member
Kelley, Colleen M., committee member
Florida State University, degree granting institution
College of Arts and Sciences, degree granting college
Department of Psychology, degree granting department
Type of Resource: text
Genre: Text
Issuance: monographic
Date Issued: 2014
Publisher: Florida State University
Place of Publication: Tallahassee, Florida
Physical Form: computer
online resource
Extent: 1 online resource (33 pages)
Language(s): English
Abstract/Description: Hindbrain glucagon-like peptide 1 (GLP-1) neurons project to numerous feeding-relevant forebrain areas. One such region is the lateral septum (LS), which plays a role in learning, motivation, and stress. We hypothesized that stimulation of GLP-1R in the LS affects food intake. Rats were implanted with unilateral cannulas targeting the LS, and intra-LS injections were made 30 min before dark cycle onset. We examined the effects of the GLP-1R agonist Exendin 4 (Ex4) at doses subthreshold for effect when delivered to the lateral ventricle (0.01 or 0.025 µg). Ex4 had no effect on feeding at 2 and 4 h into the dark phase, but the 0.025 µg dose suppressed overnight intake. We then assessed the effects of ventricle-subthreshold doses (1.0, 2.5, 5.0, or 10.0 µg) of the GLP-1R antagonist Exendin (9-39) (Ex9) vs vehicle injected into the LS. Ex9 increased chow intake at 2, 4, and 20 hours post-dark onset relative to vehicle. We assessed the role of LS GLP-1R in motivation for food by examining operant responding for sucrose on progressive ratio (PR) schedule. Intra-LS injections of Ex9 (10.0 µg) or vehicle were made 45 min prior to the start of the PR session. We also tested PR responding after a nutrient preload designed to maximize GLP-1 neuron activation. The preload strongly suppressed PR responding, but blockade of LS GLP-1R did not affect motivation for sucrose in either preload condition. The Ensure preload significantly suppressed 24-hour chow intake relative to no preload condition. However, intra-LS Ex9 treatment significantly reduced this compensatory reduction in chow intake after the preload. These experiments suggest that the LS is a relevant site for neuronal GLP-1 influence on food intake.
Identifier: FSU_migr_etd-9261 (IID)
Submitted Note: A Thesis submitted to the Department of Psychology in partial fulfillment of the requirements for the degree of Master of Science.
Degree Awarded: Fall Semester, 2014.
Date of Defense: October 1, 2014.
Keywords: Food Intake, GLP-1, Lateral Septum
Bibliography Note: Includes bibliographical references.
Advisory Committee: Diana Williams, Professor Directing Thesis; Alan Spector, Committee Member; Colleen Kelley, Committee Member.
Subject(s): Nanoscience
Persistent Link to This Record:
Owner Institution: FSU

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Terrill, S. J. (2014). Glucagon-like Peptide 1 Receptors in Lateral Septum Affect Food Intake. Retrieved from