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Effect of Nighttime Protein Intake on Fat Metabolism in Overweight and Obese Men

Title: The Effect of Nighttime Protein Intake on Fat Metabolism in Overweight and Obese Men.
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Name(s): Kinsey, Amber Whitley, author
Ormsbee, Michael J., professor directing dissertation
Contreras, Robert J. (Robert John), 1948-, university representative
Panton, Lynn B., committee member
Driscoll, Kimberly A., committee member
Florida State University, degree granting institution
College of Human Sciences, degree granting college
Department of Nutrition, Food, and Exercise Science, degree granting department
Type of Resource: text
Genre: Text
Issuance: monographic
Date Issued: 2015
Publisher: Florida State University
Place of Publication: Tallahassee, Florida
Physical Form: computer
online resource
Extent: 1 online resource (104 pages)
Language(s): English
Abstract/Description: Background: Nighttime eating, particularly before bed, has received considerable media attention in recent years. The common thought was to avoid caloric intake post-dinner and pre-sleep due to worries of weight gain and a negative impact on cardiometabolic health. It appears that minimizing nighttime caloric intake by providing a structured low calorie option with a high satiating value (e.g., greater protien content) may alter the risk for overcomsumption and long-term weight gain. Indeed, recent work from our laboratory and others have demonstrated that low-calorie, nighttime snacking options consisting primarily of protein may be beneficial. To date, no studies have investigated the impact of casein intake before bed on overnight and next morning fat metabolism in obese men. Purpose: To determine if casein protein (CAS) consumed at night before sleep will alter overnight subcutaneous abdominal adipose tissue (SCAAT) lipolysis, and next morning whole-body fat oxidation and appetite in overweight and obese men compared to a non-caloric placebo (PLA). Methods: Twelve overweight and obese men participated in this randomized, cross-over, double-blind and placebo-controlled study. Participants came to the laboratory at baseline and twice during each of the treatment periods with CAS and PLA. Each treatment period consisted of one visit in the evening and another the next morning. Participants consumed CAS or PLA and overnight lipolysis was measured with microdialysis, a minimally invasive method used to monitor SCAAT interstitial glycerol concentrations. The next morning fat oxidation and metabolism (indirect calorimetry), and appetite (visual analog scales for hunger, satiety, and desire to eat) were measured. Results: There were no significant differences in overnight SCAAT interstitial glycerol concentrations (CAS, 175.0 ± 26.5; PLA, 184.8 ± 20.7 μmol/L; p =0.77), fat oxidation (CAS, 0.76 ± 0.01; PLA, 0.76 ± 0.01; p =0.75), metabolic rate (CAS, 2126 ± 111; PLA, 2145 ± 106 kcals/day; p =0.94) or any markers of appetite between CAS and PLA. However, the participants in the present study were hyperinsulinemic (fasting insulin > 30 μUL), which may have masked any potential differences in the dependent variables. Conclusion: Despite common concern for eating at night before bed, it appears that casein protein had no impact on overnight lipolysis or whole-body fat oxidation and therefore does not appear to have any negative effects compared to a non-caloric placebo in obese men. (ClinicalTrials.gov NCT02211391)
Identifier: FSU_migr_etd-9631 (IID)
Submitted Note: A Dissertation submitted to the Department of Nutrition, Food and Exercise Sciences in partial fulfillment of the requirements for the degree of Doctor of Philosophy.
Degree Awarded: Summer Semester 2015.
Date of Defense: July 1, 2015.
Keywords: Casein, Lipolysis, Metabolism, Nighttime Eating, Obesity, Protein
Bibliography Note: Includes bibliographical references.
Advisory Committee: Michael J. Ormsbee, Professor Directing Dissertation; Robert Contreras, University Representative; Lynn B. Panton, Committee Member; Kimberly Driscoll, Committee Member.
Subject(s): Nutrition
Endocrinology
Medical sciences
Persistent Link to This Record: http://purl.flvc.org/fsu/fd/FSU_migr_etd-9631
Owner Institution: FSU

Choose the citation style.
Kinsey, A. W. (2015). The Effect of Nighttime Protein Intake on Fat Metabolism in Overweight and Obese Men. Retrieved from http://purl.flvc.org/fsu/fd/FSU_migr_etd-9631