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Working memory and intraindividual variability as neurocognitive indicators in ADHD

Title: Working memory and intraindividual variability as neurocognitive indicators in ADHD: examining competing model predictions.
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Name(s): Kofler, Michael, author
Alderson, R., author
Raiker, Joseph, author
Bolden, Jennifer, author
Sarver, Dustin, author
Rapport, Mark, author
Type of Resource: text
Genre: Text
Issuance: serial
Date Issued: 2014
Physical Form: computer
online resource
Extent: 1 online resource
Language(s): English
Abstract/Description: OBJECTIVE: The current study examined competing predictions of the default mode, cognitive neuroenergetic, and functional working memory models of attention-deficit/hyperactivity disorder (ADHD) regarding the relation between neurocognitive impairments in working memory and intraindividual variability. METHOD: Twenty-two children with ADHD and 15 typically developing children were assessed on multiple tasks measuring intraindividual reaction time (RT) variability (ex-Gaussian: tau, sigma) and central executive (CE) working memory. Latent factor scores based on multiple, counterbalanced tasks were created for each construct of interest (CE, tau, sigma) to reflect reliable variance associated with each construct and remove task-specific, test-retest, and random error. RESULTS: Bias-corrected, bootstrapped mediation analyses revealed that CE working memory accounted for 88% to 100% of ADHD-related RT variability across models, and between-group differences in RT variability were no longer detectable after accounting for the mediating role of CE working memory. In contrast, RT variability accounted for 10% to 29% of between-group differences in CE working memory, and large magnitude CE working memory deficits remained after accounting for this partial mediation. Statistical comparison of effect size estimates across models suggests directionality of effects, such that the mediation effects of CE working memory on RT variability were significantly greater than the mediation effects of RT variability on CE working memory. CONCLUSIONS: The current findings question the role of RT variability as a primary neurocognitive indicator in ADHD and suggest that ADHD-related RT variability may be secondary to underlying deficits in CE working memory.
Identifier: FSU_migr_psy_faculty_publications-0020 (IID), 10.1037/neu0000050 (DOI)
Keywords: attention-deficit/hyperactivity disorder, ADHD, working memory, variability, reaction time, ex-Gaussian
Note: This is the author's accepted manuscript of a journal article published by the American Psychological Association. Version as published available: http://psycnet.apa.org/journals/neu/28/3/459/
Citation: Kofler, M. J., Alderson, R. M., Raiker, J. S., Bolden, J., Sarver, D. E., & Rapport, M. D. (2014). Working memory and intraindividual variability as neurocognitive indicators in ADHD: Examining competing model predictions. Neuropsychology, 28(3), 459.
Subject(s): Psychology
Links: http://dx.doi.org/10.1037/neu0000050
Persistent Link to This Record: http://purl.flvc.org/fsu/fd/FSU_migr_psy_faculty_publications-0020
Owner Institution: FSU
Is Part of Series: Department of Psychology Faculty Publications.
Is Part Of: Neuropsychology.
Issue: 3, 28

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Kofler, M., Alderson, R., Raiker, J., Bolden, J., Sarver, D., & Rapport, M. (2014). Working memory and intraindividual variability as neurocognitive indicators in ADHD: examining competing model predictions. Neuropsychology. Retrieved from http://dx.doi.org/10.1037/neu0000050