You are here

BDNF Val66Met is Associated with Introversion and Interacts with 5-HTTLPR to Influence Neuroticism

Title: BDNF Val66Met is Associated with Introversion and Interacts with 5-HTTLPR to Influence Neuroticism.
Name(s): Terracciano, Antonio, author
Tanaka, Toshiko, author
Sutin, Angelina, author
Deiana, Barbara, author
Balaci, Lenuta, author
Sanna, Serena, author
Olla, Nazario, author
Maschio, Andrea, author
Uda, Manuela, author
Ferrucci, Luigi, author
Schlessinger, David, author
Costa, Paul, author
Type of Resource: text
Genre: Text
Issuance: serial
Date Issued: 2010
Physical Form: computer
online resource
Extent: 1 online resource
Language(s): English
Abstract/Description: Brain-derived neurotrophic factor (BDNF) regulates synaptic plasticity and neurotransmission, and has been linked to neuroticism, a major risk factor for psychiatric disorders. A recent genome-wide association (GWA) scan, however, found the BDNF Val66Met polymorphism (rs6265) associated with extraversion but not with neuroticism. In this study, we examine the links between BDNF and personality traits, assessed using the Revised NEO Personality Inventory (NEO-PI-R), in a sample from SardiNIA (n=1560) and the Baltimore Longitudinal Study of Aging (BLSA; n=1131). Consistent with GWA results, we found that BDNF Met carriers were more introverted. By contrast, in both samples and in a meta-analysis inclusive of published data (n=15251), we found no evidence for a main effect of BDNF Val66Met on neuroticism. Finally, on the basis of recent reports of an epistatic effect between BDNF and the serotonin transporter, we explored a Val66Met x 5-HTTLPR interaction in a larger SardiNIA sample (n=2333). We found that 5-HTTLPR LL carriers scored lower on neuroticism in the presence of the BDNF Val variant, but scored higher on neuroticism in the presence of the BDNF Met variant. Our findings support the association between the BDNF Met variant and introversion and suggest that BDNF interacts with the serotonin transporter gene to influence neuroticism.
Identifier: FSU_migr_mhs-0029 (IID), 10.1038/npp.2009.213 (DOI)
Keywords: personality, depression, BDNF Val66Met, serotonin transporter, GWA, gene–gene interaction
Uncontrolled subjects: Adolescent, Adult, Aged, Aged, 80 and over, Brain-Derived Neurotrophic Factor, Female, Heterozygote, Humans, Male, Middle Aged, Personality, Personality Tests, Polymorphism, Genetic, Sequence Analysis, DNA, Serotonin Plasma Membrane Transport Proteins, Young Adult
Note: Neuropsychopharmacology (2010) 35, 1083–1089; doi:10.1038/npp.2009.213; published online 30 December 2009
Citation: Terracciano A, Tanaka T, Sutin AR, Deiana B, Balaci L, Sanna S, Olla N, Maschio A, Uda M, Ferrucci L, Schlessinger D, & Costa PT Jr. (2010). BDNF Val66Met is associated with introversion and interacts with 5-HTTLPR to influence neuroticism. Neuropsychopharmacology, 35(5):1083-9.
Subject(s): Amino acids
Human behavior
Medical sciences
Mental illness
Persistent Link to This Record:
Host Institution: FSU
Is Part of Series: Behavioral Sciences and Social Medicine Faculty Publications.
Is Part Of: Neuropsychopharmacology.
Issue: 5, 35

Choose the citation style.
Terracciano, A., Tanaka, T., Sutin, A., Deiana, B., Balaci, L., Sanna, S., … Costa, P. (2010). BDNF Val66Met is Associated with Introversion and Interacts with 5-HTTLPR to Influence Neuroticism. Neuropsychopharmacology. Retrieved from