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Genome-Wide Association Scan of Trait Depression

Title: Genome-Wide Association Scan of Trait Depression.
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Name(s): Terracciano, Antonio, author
Tanaka, Toshiko, author
Sutin, Angelina, author
Sanna, Serena, author
Deiana, Barbara, author
Lai, Sandra, author
Uda, Manuela, author
Schlessinger, David, author
Abecasis, Gonçalo, author
Ferrucci, Luigi, author
Costa, Paul, author
Type of Resource: text
Genre: Text
Issuance: serial
Date Issued: 2010
Physical Form: computer
online resource
Extent: 1 online resource
Language(s): English
Abstract/Description: BACKGROUND: Independent of temporal circumstances, some individuals have greater susceptibility to depressive affects, such as feelings of guilt, sadness, hopelessness, and loneliness. Identifying the genetic variants that contribute to these individual differences can point to biological pathways etiologically involved in psychiatric disorders. METHODS: Genome-wide association scans for the depression scale of the Revised NEO Personality Inventory in community-based samples from a genetically homogeneous area of Sardinia, Italy (n = 3972) and from the Baltimore Longitudinal Study of Aging in the United States (n = 839). RESULTS: Meta-analytic results for genotyped or imputed single nucleotide polymorphisms indicate that the strongest association signals for trait depression were found in RORA (rs12912233; p = 6 × 10⁻⁷·), a gene involved in circadian rhythm. A plausible biological association was also found with single nucleotide polymorphisms within GRM8 (rs17864092; p = 5 × 10⁻⁶), a metabotropic receptor for glutamate, a major excitatory neurotransmitter in the central nervous system. CONCLUSIONS: These findings suggest shared genetic basis underlying the continuum from personality traits to psychopathology.
Identifier: FSU_migr_mhs-0023 (IID), 10.1016/j.biopsych.2010.06.030 (DOI)
Keywords: GWA, GWAS, depression, neuroticism, RORA, GRM8, mGlu8
Uncontrolled subjects: Adolescent, Adult, Aged, Aged, 80 and over, Baltimore, Depression, Female, Genetic Predisposition to Disease, Genome-Wide Association Study, Genotype, Humans, Italy, Male, Middle Aged, Polymorphism, Single Nucleotide
Note: Published in final edited form as: Biol Psychiatry. 2010 November 1; 68(9): 811–817. doi:10.1016/j.biopsych.2010.06.030.
Citation: Terracciano A, Tanaka T, Sutin AR, Sanna S, Deiana B, Lai S, Uda M, Schlessinger D, Abecasis GR, Ferrucci L, & Costa PT Jr. (2010). Genome-wide association scan of trait depression. Biol Psychiatry, 68(9):811-7.
Subject(s): Genetics
Genomics
Medical genetics
Medical sciences
Mental health
Social psychiatry
Mental illness
Psychiatry
Links: http://dx.doi.org/10.1016/j.biopsych.2010.06.030
Persistent Link to This Record: http://purl.flvc.org/fsu/fd/FSU_migr_mhs-0023
Owner Institution: FSU
Is Part of Series: Behavioral Sciences and Social Medicine Faculty Publications.
Is Part Of: Biological psychiatry.
Issue: 9, 68

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Terracciano, A., Tanaka, T., Sutin, A., Sanna, S., Deiana, B., Lai, S., … Costa, P. (2010). Genome-Wide Association Scan of Trait Depression. Biological Psychiatry. Retrieved from http://dx.doi.org/10.1016/j.biopsych.2010.06.030