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Neural Correlates of Neuroticism Differ by Sex Prospectively Mediate Depressive Symptoms Among Older Women

Title: The Neural Correlates of Neuroticism Differ by Sex Prospectively Mediate Depressive Symptoms Among Older Women.
Name(s): Sutin, Angelina, author
Beason-Held, Lori, author
Dotson, Vonetta, author
Resnick, Susan M., author
Costa, Paul, author
Type of Resource: text
Genre: Text
Issuance: serial
Date Issued: 2010
Physical Form: computer
online resource
Extent: 1 online resource
Language(s): English
Abstract/Description: BACKGROUND: Mood disorders in old age increase the risk of morbidity and mortality for individuals and healthcare costs for society. Trait Neuroticism, a strong risk factor for such disorders into old age, shares common genetic variance with depression, but the more proximal biological mechanisms that mediate this connection are not well understood. Further, whether sex differences in the neural correlates of Neuroticism mirror sex differences in behavioral measures is unknown. The present research identifies sex differences in the stable neural activity associated with Neuroticism and tests whether this activity prospectively mediates Neuroticism and subsequent depressive symptoms. METHODS: A total of 100 (46 female) older participants (>55years) underwent a resting-state PET scan twice, approximately two years apart, and completed measures of Neuroticism and depressive symptoms twice. RESULTS: Replicating at both time points, Neuroticism correlated positively with resting-state regional cerebral blood-flow activity in the hippocampus and midbrain in women and the middle temporal gyrus in men. For women, hippocampal activity mediated the association between Neuroticism at baseline and depressive symptoms at follow-up. The reverse mediational model was not significant. CONCLUSIONS: Neuroticism was associated with stable neural activity in regions implicated in emotional processing and regulation for women but not men. Among women, Neuroticism prospectively predicted depressive symptoms through greater activity in the right hippocampus, suggesting one neural mechanism between Neuroticism and depression for women. Identifying responsible mechanisms for the association between Neuroticism and psychiatric disorders may help guide research on pharmacological interventions for such disorders across the lifespan.
Identifier: FSU_migr_mhs-0021 (IID), 10.1016/j.jad.2010.06.004 (DOI)
Keywords: neuroticism, depression, PET Imaging, hippocampus, mediation, sex differences
Uncontrolled subjects: Aged, Baltimore, Blood Flow Velocity, Brain, Brain Mapping, Character, Depressive Disorder, Female, Humans, Image Processing, Computer-Assisted, Longitudinal Studies, Male, Mesencephalon, Middle Aged, Neurotic Disorders, Personality Inventory, Positron-Emission Tomography, Prospective Studies, Psychometrics, Regional Blood Flow, Sex Factors, Statistics as Topic, Temporal Lobe
Note: Published in final edited form as: J Affect Disord. 2010 December ; 127(1-3): 241–247. doi:10.1016/j.jad.2010.06.004
Citation: Sutin AR, Beason-Held LL, Dotson VM, Resnick SM, and Costa PT Jr. (2010). The neural correlates of Neuroticism differ by sex prospectively mediate depressive symptoms among older women. J Affect Disord, 127(1-3):241-7.
Subject(s): Geriatrics
Medical sciences
Mental health
Social psychiatry
Women -- Health and hygiene
Persistent Link to This Record:
Owner Institution: FSU
Is Part of Series: Behavioral Sciences and Social Medicine Faculty Publications.
Is Part Of: Journal of Affective Disorders.
Issue: 1-3, 127

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Sutin, A., Beason-Held, L., Dotson, V., Resnick, S. M., & Costa, P. (2010). The Neural Correlates of Neuroticism Differ by Sex Prospectively Mediate Depressive Symptoms Among Older Women. Journal Of Affective Disorders. Retrieved from