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Neuroticism, Depressive Symptoms, and Serum BDNF

Title: Neuroticism, Depressive Symptoms, and Serum BDNF.
Name(s): Terracciano, Antonio, author
Lobina, Monia, author
Piras, Maria, author
Mulas, Antonella, author
Cannas, Alessandra, author
Meirelles, Osorio, author
Sutin, Angelina, author
Zonderman, Alan, author
Uda, Manuela, author
Crisponi, Laura, author
Schlessinger, David, author
Type of Resource: text
Genre: Text
Issuance: serial
Date Issued: 2011
Physical Form: computer
online resource
Extent: 1 online resource
Language(s): English
Abstract/Description: OBJECTIVE: Animal models and clinical studies suggest that brain-derived neurotrophic factor (BDNF) is involved in the pathophysiology of depression. We test whether serum and plasma levels of BDNF are associated with trait neuroticism and its facets and with state measures of depressive symptoms. METHODS: In a community-based cohort (N = 2099), we measured serum and plasma BDNF concentrations and administered the Revised NEO Personality Inventory and the Center for Epidemiological Studies Depression Scale. Covariates included age, sex, cigarette smoking, obesity, and antidepressant use. RESULTS: Serum BDNF concentrations were inversely related to neuroticism (r = -0.074, p < .001), in particular the depression facet (r = -0.08, p < .001). Lower BDNF concentrations were also associated with severe depressive symptoms (Center for Epidemiological Studies Depression Scale ≥ 28; odds ratio = 0.906; 95% confidence interval = 0.851-0.965). The association of serum BDNF with neuroticism was independent of depressive symptoms, indicating that serum BDNF might represent a biological correlate of neuroticism and not just of transient depressive states. Plasma BDNF was not associated with measures of depression. CONCLUSIONS: Our study suggests that lower serum BDNF is associated with both a dispositional vulnerability to depression and acute depressive states in the general population.
Identifier: FSU_migr_mhs-0019 (IID), 10.1097/PSY.0b013e3182306a4f (DOI)
Keywords: neuroticism, depression, brain-derived neurotrophic factor (BDNF), serum, plasma
Uncontrolled subjects: Acute Disease, Adolescent, Adult, Age Factors, Aged, Aged, 80 and over, Brain-Derived Neurotrophic Factor, Depression, Female, Humans, Male, Middle Aged, Neurotic Disorders, Sex Factors, Young Adult
Note: Published in final edited form as: Psychosom'>">Psychosom Med. 2011 October; 73(8): 638–642. Published online 2011 September 23. doi: 10.1097/PSY.0b013e3182306a4f'>">10.1097/PSY.0b013e3182306a4f
Citation: Terracciano A, Lobina M, Piras MG, Mulas A, Cannas A, Meirelles O, Sutin AR, Zonderman AB, Uda M, Crisponi L, Schlessinger D. (2011). Neuroticism, depressive symptoms, and serum BDNF. Psychosom Med, 73(8):638-42
Subject(s): Amino acids
Medical sciences
Mental health
Social psychiatry
Mental illness
Persistent Link to This Record:
Owner Institution: FSU
Is Part of Series: Behavioral Sciences and Social Medicine Faculty Publications.
Is Part Of: Psychosomatic Medicine.
Issue: 8, 73

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Terracciano, A., Lobina, M., Piras, M., Mulas, A., Cannas, A., Meirelles, O., … Schlessinger, D. (2011). Neuroticism, Depressive Symptoms, and Serum BDNF. Psychosomatic Medicine. Retrieved from