You are here

Increased Genetic Vulnerability to Smoking at CHRNA5 in Early-Onset Smokers

Title: Increased Genetic Vulnerability to Smoking at CHRNA5 in Early-Onset Smokers.
566 views
415 downloads
Name(s): Hartz, Sarah, author
Short, Susan, author
Saccone, Nancy, author
Culverhouse, Robert, author
Chen, LiShiun, author
Schwantes-An, Tae-Hwi, author
Coon, Hilary, author
Han, Younghun, author
Stephens, Sarah, author
Sun, Juzhong, author
Chen, Xiangning, author
Ducci, Francesca, author
Dueker, Nicole, author
Franceschini, Nora, author
Frank, Josef, author
Geller, Frank, author
Gubjartsson, Daniel, author
Hansel, Nadia, author
Jiang, Chenhui, author
Keskitalo-Vuokko, Kaisu, author
Liu, Zhen, author
Lyytikäinen, Leo-Pekka, author
Michel, Martha, author
Rawal, Rajesh, author
Rosenberger, Albert, author
Scheet, Paul A. (Paul Anthony), author
Shaffer, John, author
Teumer, Alexander, author
Thompson, John, author
Vink, Jacqueline, author
Vogelzangs, Nicole, author
Wenzlaff, Angela, author
Wheeler, William, author
Xiao, Xiangjun, author
Yang, Bao-Zhu, author
Aggen, Steven, author
Balmforth, Anthony, author
Baumeister, Sebastian, author
Beaty, Terri H., author
Bennett, Siiri, author
Bergen, Andrew, author
Boyd, Heather, author
Broms, Ulla, author
Campbell, Harry, author
Chatterjee, Nilanjan, author
Chen, Jingchun, author
Cheng, Yu-Ching, author
Cichon, Sven, author
Couper, David, author
Cucca, Francesco, author
Dick, Danielle M. (Danielle Marie), author
Foroud, Tatiana, author
Furberg, Helena, author
Giegling, Ina, author
Gu, Fangyi, author
Hall, A. S. (Alistair Scott), author
Hällfors, Jenni, author
Han, Shizhong, author
Hartmann, Annette, author
Hayward, Caroline, author
Heikkilä, Kauko, author
Hewitt, John K., author
Hottenga, Jouke-Jan, author
Jensen, Majken, author
Jousilahti, Pekka, 1955-, author
Kaakinen, Marika, author
Kittner, Steven, author
Konte, Bettina, author
Korhonen, Tellervo, author
Landi, Maria-Teresa, author
Laatikainen, Tiina, author
Leppert, Mark, author
Levy, Steven, author
Mathias, Rasika, author
McNeil, Daniel, author
Medland, Sarah, author
Montgomery, Grant, author
Muley, Thomas, author
Murray, Tanda, author
Nauck, Matthias, author
North, Kari, author
Pergadia, Michele, author
Polasek, Ozren, author
Ramos, Erin Michele, author
Ripatti, Samuli, author
Risch, Angela, author
Ruczinski, Ingo, author
Rudan, Igor, author
Salomaa, Veikko, author
Schlessinger, David, author
Styrkársdóttir, Unnur, author
Terracciano, Antonio, author
Uda, Manuela, author
Willemsen, Gonneke, author
Wu, Xifeng, author
Abecasis, Gonçalo, author
Barnes, Kathleen, author
Bickeböller, Heike, author
Boerwinkle, Eric, author
Boomsma, Dorret, author
Caporaso, Neil, author
Duan, Jubao, author
Edenberg, Howard, author
Francks, Clyde, author
Gejman, Pablo, author
Gelernter, Joel, author
Grabe, Hans, author
Hops, Hyman, author
Jarvelin, Marjo-Riitta, author
Viikari, Jorma, author
Kähönen, Mika, author
Kendler, Kenneth S., 1950-, author
Lehtimäki, Terho, author
Levinson, Douglas, author
Marazita, Mary, author
Marchini, Jonathan, author
Melbye, Mads, author
Mitchell, Braxton, author
Murray, Jeffrey, author
Nöthen, Markus, author
Penninx, Brenda, author
Raitakari, Olli, author
Rietschel, Marcella, author
Rujescu, Dan, author
Samani, Nilesh J., author
Sanders, Alan, author
Schwartz, Ann, author
Shete, Sanjay, author
Shi, Jianxin, author
Spitz, Margaret R., author
Stefansson, Kari, author
Swan, Gary, author
Thorgeirsson, Thorgeir, author
Völzke, Henry, author
Wei, Qingyi, author
Wichmann, H.-Erich (Heinz-Erich), 1946-, author
Amos, Christopher I., author
Breslau, Naomi, author
Cannon, Dale S., author
Ehringer, Marissa, author
Grucza, Richard, author
Hatsukami, Dorothy, author
Heath, Andrew, author
Johnson, Eric, author
Kaprio, Jaakko, 1951-, author
Madden, Pamela, author
Martin, Nicholas G., author
Stevens, Victoria, author
Stitzel, Jerry, author
Weiss, Robert, author
Kraft, Peter, author
Bierut, Laura, author
Type of Resource: text
Genre: Text
Issuance: serial
Date Issued: 2012
Physical Form: computer
online resource
Extent: 1 online resource
Language(s): English
Abstract/Description: CONTEXT: Recent studies have shown an association between cigarettes per day (CPD) and a nonsynonymous single-nucleotide polymorphism in CHRNA5, rs16969968. OBJECTIVE: To determine whether the association between rs16969968 and smoking is modified by age at onset of regular smoking. DATA SOURCES: Primary data. STUDY SELECTION: Available genetic studies containing measures of CPD and the genotype of rs16969968 or its proxy. DATA EXTRACTION: Uniform statistical analysis scripts were run locally. Starting with 94,050 ever-smokers from 43 studies, we extracted the heavy smokers (CPD >20) and light smokers (CPD ≤10) with age-at-onset information, reducing the sample size to 33,348. Each study was stratified into early-onset smokers (age at onset ≤16 years) and late-onset smokers (age at onset >16 years), and a logistic regression of heavy vs light smoking with the rs16969968 genotype was computed for each stratum. Meta-analysis was performed within each age-at-onset stratum. DATA SYNTHESIS: Individuals with 1 risk allele at rs16969968 who were early-onset smokers were significantly more likely to be heavy smokers in adulthood (odds ratio [OR] = 1.45; 95% CI, 1.36-1.55; n = 13,843) than were carriers of the risk allele who were late-onset smokers (OR = 1.27; 95% CI, 1.21-1.33, n = 19,505) (P = .01). CONCLUSION: These results highlight an increased genetic vulnerability to smoking in early-onset smokers.
Identifier: FSU_migr_geriatrics_faculty_publications-0040 (IID), 10.1001/archgenpsychiatry.2012.124 (DOI)
Keywords: gene-environment interaction, genetic predisposition to disease, nerve tissue proteins, nicotine, polymorphism, single nucleotide, receptors, Nicotinic, Severity of Illness Index, smoking, tobacco use
Uncontrolled subjects: Adolescent, Adolescent Development, Adult, Age of Onset, Europe, Female, Gene-Environment Interaction, Genetic Association Studies, Genetic Predisposition to Disease, Humans, Male, Nerve Tissue Proteins, Nicotine, Polymorphism, Single Nucleotide, Receptors, Nicotinic, Severity of Illness Index, Smoking, Tobacco Use Disorder
Note: Arch Gen Psychiatry. Author manuscript; available in PMC 2013 August 1. Published in final edited form as:'>http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&retmode=ref&cmd=prlinks&id=22868939"> Arch Gen Psychiatry. 2012 August; 69(8): 854–860. doi: 10.1001/archgenpsychiatry.2012.124'>http://dx.doi.org/10.1001%2Farchgenpsychiatry.2012.124">10.1001/archgenpsychiatry.2012.124
Citation: Hartz SM, Short SE, Saccone NL, Culverhouse R, Chen L, Schwantes-An TH, Coon H, Han Y, Stephens SH, Sun J, Chen X, Ducci F, Dueker N, Franceschini N, Frank J, Geller F, Gubjartsson D, Hansel NN, Jiang C, Keskitalo-Vuokko K, Liu Z, Lyytikäinen LP, Michel M, Rawal R, Rosenberger A, Scheet P, Shaffer JR, Teumer A, Thompson JR, Vink JM, Vogelzangs N, Wenzlaff AS, Wheeler W, Xiao X, Yang BZ, Aggen SH, Balmforth AJ, Baumeister SE, Beaty T, Bennett S, Bergen AW, Boyd HA, Broms U, Campbell H, Chatterjee N, Chen J, Cheng YC, Cichon S, Couper D, Cucca F, Dick DM, Foroud T, Furberg H, Giegling I, Gu F, Hall AS, Hällfors J, Han S, Hartmann AM, Hayward C, Heikkilä K, Hewitt JK, Hottenga JJ, Jensen MK, Jousilahti P, Kaakinen M, Kittner SJ, Konte B, Korhonen T, Landi MT, Laatikainen T, Leppert M, Levy SM, Mathias RA, McNeil DW, Medland SE, Montgomery GW, Muley T, Murray T, Nauck M, North K, Pergadia M, Polasek O, Ramos EM, Ripatti S, Risch A, Ruczinski I, Rudan I, Salomaa V, Schlessinger D, Styrkársdóttir U, Terracciano A, Uda M, Willemsen G, Wu X, Abecasis G, Barnes K, Bickeböller H, Boerwinkle E, Boomsma DI, Caporaso N, Duan J, Edenberg HJ, Francks C, Gejman PV, Gelernter J, Grabe HJ, Hops H, Jarvelin MR, Viikari J, Kähönen M, Kendler KS, Lehtimäki T, Levinson DF, Marazita ML, Marchini J, Melbye M, Mitchell BD, Murray JC, Nöthen MM, Penninx BW, Raitakari O, Rietschel M, Rujescu D, Samani NJ, Sanders AR, Schwartz AG, Shete S, Shi J, Spitz M, Stefansson K, Swan GE, Thorgeirsson T, Völzke H, Wei Q, Wichmann HE, Amos CI, Breslau N, Cannon DS, Ehringer M, Grucza R, Hatsukami D, Heath A, Johnson EO, Kaprio J, Madden P, Martin NG, Stevens VL, Stitzel JA, Weiss RB, Kraft P, & Bierut LJ. (2012) Increased Genetic Vulnerability to Smoking at CHRNA5 in Early-Onset Smokers. Arch Gen Psychiatry, 69, 854-60.
Subject(s): Human behavior
Genetics
Genomics
Health
Medicine
Medical sciences
Pathology
Symptoms
Drug addiction
Substance abuse
Links: http://dx.doi.org/10.1001/archgenpsychiatry.2012.124
Persistent Link to This Record: http://purl.flvc.org/fsu/fd/FSU_migr_geriatrics_faculty_publications-0040
Owner Institution: FSU
Is Part of Series: Department of Geriatrics Faculty Publications.
Is Part Of: Archives of General Psychiatry.
Issue: 8, 69

Choose the citation style.
Hartz, S., Short, S., Saccone, N., Culverhouse, R., Chen, L. S., Schwantes-An, T. -H., … Bierut, L. (2012). Increased Genetic Vulnerability to Smoking at CHRNA5 in Early-Onset Smokers. Archives Of General Psychiatry. Retrieved from http://dx.doi.org/10.1001/archgenpsychiatry.2012.124