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Heritability of Cardiovascular and Personality Traits in 6,148 Sardinians

Title: Heritability of Cardiovascular and Personality Traits in 6,148 Sardinians.
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Name(s): Pilia, Giuseppe, author
Chen, Wei-Min, author
Scuteri, Angelo, author
Orrú, Marco, author
Albai, Giuseppe, author
Dei, Mariano, author
Lai, Sandra, author
Usala, Gianluca, author
Lai, Monica, author
Loi, Paola, author
Mameli, Cinzia, author
Vacca, Loredana, author
Deiana, Manila, author
Olla, Nazario, author
Masala, Marco, author
Cao, Antonio, author
Najjar, Samer, author
Terracciano, Antonio, author
Nedorezov, Timur, author
Sharov, Alexei, author
Zonderman, Alan, author
Abecasis, Gonçalo, author
Costa, Paul, author
Lakatta, Edward, author
Schlessinger, David, author
Type of Resource: text
Genre: Text
Issuance: serial
Date Issued: 2006
Physical Form: computer
online resource
Extent: 1 online resource
Language(s): English
Abstract/Description: In family studies, phenotypic similarities between relatives yield information on the overall contribution of genes to trait variation. Large samples are important for these family studies, especially when comparing heritability between subgroups such as young and old, or males and females. We recruited a cohort of 6,148 participants, aged 14-102 y, from four clustered towns in Sardinia. The cohort includes 34,469 relative pairs. To extract genetic information, we implemented software for variance components heritability analysis, designed to handle large pedigrees, analyze multiple traits simultaneously, and model heterogeneity. Here, we report heritability analyses for 98 quantitative traits, focusing on facets of personality and cardiovascular function. We also summarize results of bivariate analyses for all pairs of traits and of heterogeneity analyses for each trait. We found a significant genetic component for every trait. On average, genetic effects explained 40% of the variance for 38 blood tests, 51% for five anthropometric measures, 25% for 20 measures of cardiovascular function, and 19% for 35 personality traits. Four traits showed significant evidence for an X-linked component. Bivariate analyses suggested overlapping genetic determinants for many traits, including multiple personality facets and several traits related to the metabolic syndrome; but we found no evidence for shared genetic determinants that might underlie the reported association of some personality traits and cardiovascular risk factors. Models allowing for heterogeneity suggested that, in this cohort, the genetic variance was typically larger in females and in younger individuals, but interesting exceptions were observed. For example, narrow heritability of blood pressure was approximately 26% in individuals more than 42 y old, but only approximately 8% in younger individuals. Despite the heterogeneity in effect sizes, the same loci appear to contribute to variance in young and old, and in males and females. In summary, we find significant evidence for heritability of many medically important traits, including cardiovascular function and personality. Evidence for heterogeneity by age and sex suggests that models allowing for these differences will be important in mapping quantitative traits.
Identifier: FSU_migr_geriatrics_faculty_publications-0033 (IID), 10.1371/journal.pgen.0020132 (DOI)
Keywords: aging, cardiovascular diseases, cardiovascular physiological phenomena, chromosomes, genes, mitochondrial, multifactorial inheritance, personality, quantitative trait, sex characteristics, siblings
Uncontrolled subjects: Adolescent, Adult, Aged, Aged, 80 and over, Aging, Analysis of Variance, Cardiovascular Diseases, Cardiovascular Physiological Phenomena, Chromosomes, Human, X, Cohort Studies, Female, Genes, Mitochondrial, Humans, Italy, Male, Middle Aged, Models, Genetic, Multifactorial Inheritance, Personality, Quantitative Trait, Heritable, Sex Characteristics, Siblings
Note: Originally published in PLoS'>http://www.plosgenetics.org/article/info%3Adoi%2F10.1371%2Fjournal.pgen.0020132">PLoS Genetics.
Citation: Pilia G, Chen W, Scuteri A, Orrú M, Albai G, Dei M, Lai S, Usala G, Lai M, Loi P, Mameli C, Vacca L, Deiana M, Olla N, Masala M, Cao A, Najjar SS, Terracciano A, Nedorezov T, Sharov A, Zonderman AB, Abecasis GR, Costa PT Jr, Lakatta E, & Schlessinger D (2006). Heritability of cardiovascular and personality traits in 6,148 Sardinians. PloS Genetics, 2: e132; 1207-1223.
Subject(s): Cardiology
Genetics
Genomics
Medical genetics
Medical sciences
Personality
Social aspects
Psychiatry
Psychology
Links: http://dx.doi.org/10.1371/journal.pgen.0020132
Persistent Link to This Record: http://purl.flvc.org/fsu/fd/FSU_migr_geriatrics_faculty_publications-0033
Owner Institution: FSU
Is Part of Series: Department of Geriatrics Faculty Publications.
Is Part Of: PLoS Genetics.
Issue: 8, 2

Choose the citation style.
Pilia, G., Chen, W. -M., Scuteri, A., Orrú, M., Albai, G., Dei, M., … Schlessinger, D. (2006). Heritability of Cardiovascular and Personality Traits in 6,148 Sardinians. Plos Genetics. Retrieved from http://dx.doi.org/10.1371/journal.pgen.0020132