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Meta-Analysis and Imputation Refines the Association of 15q25 with Smoking Quantity

Title: Meta-Analysis and Imputation Refines the Association of 15q25 with Smoking Quantity.
Name(s): Liu, Jason, author
Tozzi, Federica, author
Waterworth, Dawn, author
Pillai, Sreekumar, author
Muglia, Pierandrea, author
Middleton, Lefkos, author
Berrettini, Wade, author
Knouff, Christopher, author
Yuan, Xin, author
Waeber, Gérard, author
Vollenweider, Peter, author
Preisig, Martin, author
Wareham, Nicholas, author
Zhao, Jing, author
Loos, Ruth, author
Barroso, Inês, author
Khaw, Kay-Tee, author
Grundy, Scott M., author
Barter, Philip, author
Mahley, Robert, author
Kesaniemi, Antero, author
McPherson, Ruth, author
Vincent, John, author
Strauss, John, author
Kennedy, James, author
Farmer, Anne, author
McGuffin, Peter, author
Day, Richard, author
Matthews, Keith, author
Bakke, Per, author
Gulsvik, A. (Amund), author
Lucae, Susanne, author
Ising, Marcus, author
Brueckl, Tanja, author
Horstmann, Sonja, author
Wichmann, H.-Erich (Heinz-Erich), 1946-, author
Rawal, Rajesh, author
Dahmen, Norbert, author
Lamina, Claudia, author
Polasek, Ozren, author
Zgaga, Lina, author
Huffman, Jennifer, author
Campbell, Susan, author
Kooner, Jaspal, author
Chambers, John, author
Burnett, Mary, author
Devaney, Joseph, author
Pichard, Augusto, author
Kent, Kenneth, author
Satler, Lowell, author
Lindsay, Joseph, author
Waksman, Ron, author
Epstein, Stephen, author
Wilson, James F. (James Flett), author
Wild, Sarah, author
Campbell, Harry, author
Vitart, Veronique, author
Reilly, Muredach, author
Li, Mingyao, author
Qu, Liming, author
Wilensky, Robert, author
Matthai, William, author
Hakonarson, Hakon, author
Rader, Daniel, author
Franke, Andre, author
Wittig, Michael, author
Schäfer, Arne, author
Uda, Manuela, author
Terracciano, Antonio, author
Xiao, Xiangjun, author
Busonero, Fabio, author
Scheet, Paul A. (Paul Anthony), author
Schlessinger, David, author
St Clair, David, author
Rujescu, Dan, author
Abecasis, Gonçalo, author
Grabe, Hans, author
Teumer, Alexander, author
Völzke, Henry, author
Petersmann, Astrid, author
John, Ulrich, author
Rudan, Igor, author
Hayward, Caroline, author
Wright, Alan, author
Kolcic, Ivana, author
Wright, Benjamin, author
Thompson, John, author
Balmforth, Anthony, author
Hall, A. S. (Alistair Scott), author
Samani, Nilesh J., author
Anderson, Carl, author
Ahmad, Tariq, author
Mathew, Christopher, author
Parkes, Miles, author
Satsangi, Jack, author
Caulfield, Mark, author
Munroe, Patricia, author
Farrall, Martin, author
Dominiczak, A. F., author
Worthington, Jane, author
Thomson, Wendy, author
Eyre, Steve, author
Barton, Anne, author
Mooser, Vincent, author
Francks, Clyde, author
Marchini, Jonathan, author
Type of Resource: text
Genre: Text
Issuance: serial
Date Issued: 2010
Physical Form: computer
online resource
Extent: 1 online resource
Language(s): English
Abstract/Description: Smoking is a leading global cause of disease and mortality. We established the Oxford-GlaxoSmithKline study (Ox-GSK) to perform a genome-wide meta-analysis of SNP association with smoking-related behavioral traits. Our final data set included 41,150 individuals drawn from 20 disease, population and control cohorts. Our analysis confirmed an effect on smoking quantity at a locus on 15q25 (P = 9.45 x 10(-19)) that includes CHRNA5, CHRNA3 and CHRNB4, three genes encoding neuronal nicotinic acetylcholine receptor subunits. We used data from the 1000 Genomes project to investigate the region using imputation, which allowed for analysis of virtually all common SNPs in the region and offered a fivefold increase in marker density over HapMap2 (ref. 2) as an imputation reference panel. Our fine-mapping approach identified a SNP showing the highest significance, rs55853698, located within the promoter region of CHRNA5. Conditional analysis also identified a secondary locus (rs6495308) in CHRNA3.
Identifier: FSU_migr_geriatrics_faculty_publications-0018 (IID), 10.1038/ng.572 (DOI)
Keywords: chromosome mapping, chromosomes, genetic markers, genome, neurons, polymorphism, single nucleotide, receptors, Nicotinic, smoking
Uncontrolled subjects: Adult, Aged, Alleles, Chromosome Mapping, Chromosomes, Human, Pair 15, Cohort Studies, Female, Genetic Markers, Genome, Human, Humans, Male, Middle Aged, Models, Genetic, Neurons, Polymorphism, Single Nucleotide, Receptors, Nicotinic, Smoking
Note: Published in final edited form as:'>"> Nat Genet. 2010 May; 42(5): 436–440. Published online 2010 April 25. doi: 10.1038/ng.572'>">10.1038/ng.572
Citation: Liu JZ, Tozzi F, Waterworth DM, Pillai SG, Muglia P, Middleton L, Berrettini W, Knouff CW, Yuan X, Waeber G, Vollenweider P, Preisig M, Wareham NJ, Zhao JH, Loos RJ, Barroso I, Khaw KT, Grundy S, Barter P, Mahley R, Kesaniemi A, McPherson R, Vincent JB, Strauss J, Kennedy JL, Farmer A, McGuffi n P, Day R, Matthews K, Bakke P, Gulsvik A, Lucae S, Ising M, Brueckl T, Horstmann S, Wichmann HE, Rawal R, Dahmen N, Lamina C, Polasek O, Zgaga L, Huffman J, Campbell S, Kooner J, Chambers JC, Burnett MS, Devaney JM, Pichard AD, Kent KM, Satler L, Lindsay JM, Waksman R, Epstein S, Wilson JF, Wild SH, Campbell H, Vitart V, Reilly MP, Li M, Qu L, Wilensky R, Matthai W, Hakonarson HH, Rader DJ, Franke A, Wittig M, Schäfer A, Uda M, Terracciano A, Xiao X, Busonero F, Scheet P, Schlessinger D, Clair DS, Rujescu D, Abecasis GR, Grabe HJ, Teumer A, Völzke H, Petersmann A, John U, Rudan I, Hayward C, Wright AF, Kolcic I, Wright BJ, Thompson JR, Balmforth AJ, Hall AS, Samani NJ, Anderson CA, Ahmad T, Mathew CG, Parkes M, Satsangi J, Caulfi eld M, Munroe PB, Farrall M, Dominiczak A, Worthington J, Thomson W, Eyre S, Barton A; The Wellcome Trust Case Control Consortium, Mooser V, Francks C, & Marchini J. (2010). Meta-analysis and imputation refines the association of 15q25 with smoking quantity. Nature Genetics, 42, 436-440.
Subject(s): Genetics
Mental health
Medical sciences
Social aspects
Drug addiction
Substance abuse
Persistent Link to This Record:
Host Institution: FSU
Is Part of Series: Department of Geriatrics Faculty Publications.
Is Part Of: Nature Genetics.
Issue: 5, 42

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Liu, J., Tozzi, F., Waterworth, D., Pillai, S., Muglia, P., Middleton, L., … Marchini, J. (2010). Meta-Analysis and Imputation Refines the Association of 15q25 with Smoking Quantity. Nature Genetics. Retrieved from