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Plasma BDNF Concentration, Val66Met Genetic Variant and Depression-Related Personality Traits

Title: Plasma BDNF Concentration, Val66Met Genetic Variant and Depression-Related Personality Traits.
Name(s): Terracciano, Antonio, author
Martin, B., author
Ansari, D., author
Tanaka, Toshiko, author
Ferrucci, Luigi, author
Maudsley, S., author
Mattson, M., author
Costa, Paul, author
Type of Resource: text
Genre: Text
Issuance: serial
Date Issued: 2010
Physical Form: computer
online resource
Extent: 1 online resource
Language(s): English
Abstract/Description: Brain-derived neurotrophic factor (BDNF) regulates synaptic plasticity and neurogenesis, and BDNF plasma and serum levels have been associated with depression, Alzheimer's disease, and other psychiatric and neurodegenerative disorders. In a relatively large community sample, drawn from the Baltimore Longitudinal Study of Aging (BLSA), we examine whether BDNF plasma concentration is associated with the Val66Met functional polymorphism of the BDNF gene (n = 335) and with depression-related personality traits assessed with the NEO-PI-R (n = 391). Plasma concentration of BDNF was not associated with the Val66Met variant in either men or women. However, in men, but not in women, BDNF plasma level was associated with personality traits linked to depression. Contrary to the notion that low BDNF is associated with negative outcomes, we found lower plasma levels in men who score lower on depression and vulnerability to stress (two facets of Neuroticism) and higher on Conscientiousness and Extraversion. These findings challenge the prevailing hypothesis that lower peripheral levels of BDNF are a marker of depression.
Identifier: FSU_migr_geriatrics_faculty_publications-0016 (IID), 10.1111/j.1601-183X.2010.00579.x (DOI)
Keywords: Brain derived neurotrophic factor, BDNF Val66Met, plasma, personality, depression, NEO-PI-R
Uncontrolled subjects: Adult, Aged, Aged, 80 and over, Aging, Biological Markers, Brain-Derived Neurotrophic Factor, Depression, Female, Genetic Variation, Humans, Male, Middle Aged, Personality, Polymorphism, Single Nucleotide, Reference Values, Sex Factors, Statistics, Nonparametric
Note: Published in final edited form as:'>"> Genes Brain Behav. 2010 July; 9(5): 512–518. Published online 2010 March 22. doi: 10.1111/j.1601-183X.2010.00579.x'>">10.1111/j.1601-183X.2010.00579.x
Citation: Terracciano A*, Martin B*, Ansari D, Tanaka T, Ferrucci L, Maudsley S, Mattson MP, & Costa PT Jr. (2010). Plasma BDNF concentration, Val66Met genetic variant, and depression-related personality traits. Genes, Brain and Behavior 9, 512-518. *Contributed equally to the work.
Subject(s): Behavior
Human behavior
Netherlands -- Civilization
Mental health
Medical genetics
Medical sciences
Social psychiatry
Social aspects
Persistent Link to This Record:
Owner Institution: FSU
Is Part of Series: Department of Geriatrics Faculty Publications.
Is Part Of: Genes, Brain, and Behavior.
Issue: 5, 9

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Terracciano, A., Martin, B., Ansari, D., Tanaka, T., Ferrucci, L., Maudsley, S., … Costa, P. (2010). Plasma BDNF Concentration, Val66Met Genetic Variant and Depression-Related Personality Traits. Genes, Brain, And Behavior. Retrieved from