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Alternative to the Search for Single Polymorphisms

Title: An Alternative to the Search for Single Polymorphisms: Toward Molecular Personality Scales for the Five-Factor Model.
Name(s): McCrae, Robert R., author
Scally, Matthew, author
Terracciano, Antonio, author
Abecasis, Gonçalo, author
Costa, Paul, author
Type of Resource: text
Genre: Text
Issuance: serial
Date Issued: 2010
Physical Form: computer
online resource
Extent: 1 online resource
Language(s): English
Abstract/Description: There is growing evidence that personality traits are affected by many genes, all of which have very small effects. As an alternative to the largely unsuccessful search for individual polymorphisms associated with personality traits, the authors identified large sets of potentially related single nucleotide polymorphisms (SNPs) and summed them to form molecular personality scales (MPSs) with from 4 to 2,497 SNPs. Scales were derived from two thirds of a large (N = 3,972) sample of individuals from Sardinia who completed the Revised NEO Personality Inventory (P. T. Costa, Jr., & R. R. McCrae, 1992) and were assessed in a genomewide association scan. When MPSs were correlated with the phenotype in the remaining one third of the sample, very small but significant associations were found for 4 of the 5e personality factors when the longest scales were examined. These data suggest that MPSs for Neuroticism, Openness to Experience, Agreeableness, and Conscientiousness (but not Extraversion) contain genetic information that can be refined in future studies, and the procedures described here should be applicable to other quantitative traits.
Identifier: FSU_migr_geriatrics_faculty_publications-0015 (IID), 10.1037/a0020964 (DOI)
Keywords: Genome-wide association study, personality assessment, founder effect, Five-Factor Model
Uncontrolled subjects: Adolescent, Adult, Aged, Aged, 80 and over, Female, Founder Effect, Genome-Wide Association Study, Humans, Italy, Male, Middle Aged, Molecular Diagnostic Techniques, Personality, Personality Assessment, Personality Inventory, Polymorphism, Single Nucleotide, Reproducibility of Results
Note: Published in final edited form as:'>"> J Pers Soc Psychol. 2010 December; 99(6): 1014–1024. doi: 10.1037/a0020964'>">10.1037/a0020964
Citation: McCrae RR, Scally M, Terracciano A, Abecasis GR, & Costa PT Jr. (2010). An alternative to the search for single polymorphisms: Toward molecular personality scales for the Five-Factor Model. Journal of Personality and Social Psychology, 99, 1014-1024.
Subject(s): Behavior
Human behavior
Medical sciences
Social aspects
Persistent Link to This Record:
Owner Institution: FSU
Is Part of Series: Department of Geriatrics Faculty Publications.
Is Part Of: Journal of Personality and Social Psychology.
Issue: 6, 99

Choose the citation style.
McCrae, R. R., Scally, M., Terracciano, A., Abecasis, G., & Costa, P. (2010). An Alternative to the Search for Single Polymorphisms: Toward Molecular Personality Scales for the Five-Factor Model. Journal Of Personality And Social Psychology. Retrieved from