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Longevity Candidate Genes and Their Association with Personality Traits in the Elderly

Title: Longevity Candidate Genes and Their Association with Personality Traits in the Elderly.
Name(s): Luciano, Michelle, author
Lopez, Lorna, author
de Moor, Marleen, author
Harris, Sarah, author
Davies, Gail, author
Nutile, Teresa, author
Krueger, Robert F., author
Esko, Tönu, author
Schlessinger, David, author
Toshiko, Tanaka, author
Derringer, Jaime, author
Realo, Anu, author
Hansell, Narelle, author
Pergadia, Michele, author
Pesonen, Anu-Katriina, author
Sanna, Serena, author
Terracciano, Antonio, author
Madden, Pamela, author
Penninx, Brenda, author
Spinhoven, Philip, author
Hartman, Catherina, author
Oostra, Ben A., 1946-, author
Janssens, A., author
Eriksson, Johan, author
Starr, John M., author
Cannas, Alessandra, author
Ferrucci, Luigi, author
Metspalu, Andres, author
Wright, Margeret, author
Heath, Andrew, author
van Duijn, Cornelia, author
Bierut, Laura, author
Raikkonen, Katri, author
Martin, Nicholas G., author
Ciullo, Marina, author
Rujescu, Dan, author
Boomsma, Dorret, author
Deary, Ian J., author
Type of Resource: text
Genre: Text
Issuance: serial
Date Issued: 2012
Physical Form: computer
online resource
Extent: 1 online resource
Language(s): English
Abstract/Description: Human longevity and personality traits are both heritable and are consistently linked at the phenotypic level. We test the hypothesis that candidate genes influencing longevity in lower organisms are associated with variance in the five major dimensions of human personality (measured by the NEO-FFI and IPIP inventories) plus related mood states of anxiety and depression. Seventy single nucleotide polymorphisms (SNPs) in six brain expressed, longevity candidate genes (AFG3L2, FRAP1, MAT1A, MAT2A, SYNJ1, and SYNJ2) were typed in over 1,000 70-year old participants from the Lothian Birth Cohort of 1936 (LBC1936). No SNPs were associated with the personality and psychological distress traits at a Bonferroni corrected level of significance (P < 0.0002), but there was an over-representation of nominally significant (P < 0.05) SNPs in the synaptojanin-2 (SYNJ2) gene associated with agreeableness and symptoms of depression. Eight SNPs which showed nominally significant association across personality measurement instruments were tested in an extremely large replication sample of 17,106 participants. SNP rs350292, in SYNJ2, was significant: the minor allele was associated with an average decrease in NEO agreeableness scale scores of 0.25 points, and 0.67 points in the restricted analysis of elderly cohorts (most aged >60 years). Because we selected a specific set of longevity genes based on functional genomics findings, further research on other longevity gene candidates is warranted to discover whether they are relevant candidates for personality and psychological distress traits.
Identifier: FSU_migr_geriatrics_faculty_publications-0013 (IID), 10.1002/ajmg.b.32013 (DOI)
Keywords: NEO personality, IPIP personality, anxiety, depressive symptoms, ageing, genetics
Uncontrolled subjects: Adolescent, Adult, Aged, Aged, 80 and over, Alleles, Anxiety Disorders, Cohort Studies, Depression, Female, Genetic Markers, Genotype, Haplotypes, Humans, Longevity, Male, Middle Aged, Personality Disorders, Personality Tests, Phenotype, Phosphoric Monoester Hydrolases, Polymerase Chain Reaction, Polymorphism, Single Nucleotide, Young Adult
Note: Published in final edited form as:'>"> Am J Med Genet B Neuropsychiatr Genet. 2012 March; 159B(2): 192–200. Published online 2011 December 27. doi: 10.1002/ajmg.b.32013'>">10.1002/ajmg.b.32013
Citation: Luciano M, Lopez LM, de Moor MH, Harris SE, Davies G, Nutile T, Krueger RF, Esko T, Schlessinger D, Toshiko T, Derringer JL, Realo A, Hansell NK, Pergadia ML, Pesonen AK, Sanna S, Terracciano A, Madden PA, Penninx B, Spinhoven P, Hartman CA, Oostra BA, Janssens AC, Eriksson JG, Starr JM, Cannas A, Ferrucci L, Metspalu A, Wright MJ, Heath AC, van Duijn CM, Bierut LJ, Raikkonen K, Martin NG, Ciullo M, Rujescu D, Boomsma DI, & Deary IJ (2012). Longevity candidate genes and their association with personality traits in the elderly. American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics, 159B, 192-200.
Subject(s): Human behavior
Mental health
Medical genetics
Medical sciences
Social psychiatry
Mental illness
Social aspects
Persistent Link to This Record:
Owner Institution: FSU
Is Part of Series: Department of Geriatrics Faculty Publications.
Is Part Of: American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics.
Issue: 2, 159B

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Luciano, M., Lopez, L., De Moor, M., Harris, S., Davies, G., Nutile, T., … Deary, I. J. (2012). Longevity Candidate Genes and Their Association with Personality Traits in the Elderly. American Journal Of Medical Genetics. Part B, Neuropsychiatric Genetics. Retrieved from